灯盏细辛注射液对不稳定型心绞痛的临床研究  

The Clinical Research of DZXX Injection in the Treatment of Unstable Angina Pectoris

作　　者：李铁[1] 杨柳 

机构地区：[1]长沙市中心医院,湖南长沙410000 [2]中南大学湘雅医院

出　　处：《中外医学研究》2014年第32期20-22,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察灯盏细辛注射液治疗不稳定型心绞痛患者的临床疗效,并初步探讨其治疗作用是否与其抑制炎症反应有关。方法:选取笔者所在医院2011年6月-2012年5月收治的80例不稳定型心绞痛患者,按照随机数字表法将其分为治疗组和对照组各40例,两组均给予常规治疗,治疗组在常规治疗的基础上给予灯盏细辛注射液治疗,观察两组患者的临床疗效及心电图疗效。应用酶联免疫分析法检测患者血清中C-反应蛋白、白细胞介素6和肿瘤坏死因子α的表达,并对两组以上指标进行观察比较。结果:治疗组的临床总有效率87.5%和心电图总有效率85.0%均明显高于对照组的65.0%和62.5%,差异均有统计学意义(P<0.05)。两组在用药前血清中的白介素6、C-反应蛋白和肿瘤坏死因子α表达均无明显差异(P>0.05);治疗组用药后血清中的白介素6、C-反应蛋白和肿瘤坏死因子α表达水平均明显低于对照组,差异均有统计学意义(P<0.05)。结论:灯盏细辛注射液可显著改善冠心病不稳定型心绞痛患者的临床疗效,为其临床应用提供了进一步的理论依据和实践支持。Objective：To observe the clinical effect of DZXX injection in the treatment of unstable angina pectoris.Method：Eighty patients with coronary heart disease in our hospital from June 2011 to May 2012 were selected,they were divided into the treatment group and the control group according to the random number table method,40 cases in each group.The two groups were given conventional therapy,and the treatment group was given DZXX injection on the basis of conventional therapy.The clinical effect and ECG efficacy of two groups were compared,and ELISA was used to detect the protein levels of CRP,IL-6 and TNF-αin blood serum,and the above indexes of two groups were observed and compared.Result：The total effective rate of treatment and ECG in treatment group were 87.5%and 85.0%,which were significantly higher than 65.0%and 62.5%in control group,the differences were statistically significant（P〈0.05）. There was no significant difference in the protein levels of CRP,IL-6 and TNF-αin blood serum between two groups before medication.The protein levels of CRP,IL-6 and TNF-αin blood serum in treatment group after medication were significantly lower than those in control group,the differences were statistically significant（P〈0.05）.Conclusion：Combination with DZXX injection and regular drugs can achieve better therapeutic effect in the treatment of unstable angina pectoris,which provide further theoretical and practical support for its clinical application.

关 键 词：灯盏细辛注射液 不稳定型心绞痛 临床研究 

分 类 号：R541.4[医药卫生—心血管疾病]