不同产地广藿香药材质量比较研究  

Comparison of Different Habitats of Pogostemon Cablin Quality

作　　者：牟鸣[1] 

机构地区：[1]四川省达州市中心医院药学部,四川达州635000

出　　处：《中国药业》2014年第22期42-44,共3页China Pharmaceuticals

摘　　要：目的优化广藿香挥发油的提取工艺,建立同时测定广藿香酮和百秋李醇含量的方法,比较不同产地广藿香药材的质量。方法采用正交试验考察广藿香挥发油的最佳提取工艺;采用气相色谱法同时测定不同产地广藿香挥发油中百秋李醇和广藿香酮的含量,以百秋李醇和广藿香酮的总含量与挥发油收率为指标评价不同产地广藿香药材的质量。结果广藿香挥发油最佳提取工艺为加8倍量水浸泡4 h,蒸馏提取4 h;建立的含量测定方法线性关系良好,准确度高,稳定可靠。结论优选的提取工艺科学合理,适合广藿香挥发油的工业化生产;建立的百秋李醇和广藿香酮测定方法准确可靠、易于操作、重复性好,适用于广藿香药材的质量控制;5个不同产地的广藿香药材在挥发油收率、百秋李醇和广藿香酮总含量等的差异均较大。Objective To optimize the extraction process of patchouli volatile oil,to establish a simultaneous determination method of the patchoulenone and patchouli alcohol contents,and to compare the qualities of the Pogostemon cablin from different habitats. Methods The optimal extraction technology of patchouli volatile oil was determined with the orthogonal experiment;the gas chromatography method was adopted to simultaneously determining the content of patchoulenone and patchouli alcohol. The qualities of the patchouli medicinal material from different habitats were evaluated by the total content of patchoulenone and patchouli alcohol,as well as the yield of volatile oil. Results The optimal extraction of patchouli volatile oil was adding 8 times the amount of water,soaking for 4 h,then con-ducting distillation extraction for 4 h;the established content determination method had good linearity and high accuracy,and was stable and reliable. Conclusion The optimized extraction technology is scientific and reasonable and suitable for the industrialized production of patchouli volatile oil;the established the content determination method of patchoulenone and patchouli alcohol is accurate,reliable and easy to operate with good reproducibility,which is suitable for the quality control of Pogostemon cablin;Pogostemon cablin from 5 dif-ferent habitats has great differences in the aspects of yield of volatile oil and the total contents of patchoulenone and patchouli alcohol.

关 键 词：广藿香 百秋李醇 广藿香酮 提取工艺 产地 

分 类 号：TQ461[化学工程—制药化工] R284.2[医药卫生—中药学]