肝细胞生长因子抑制剂——NK4的抗肿瘤作用  

NK4 with Anti-tumor Activity: A Competitive Antagonist against HGF

作　　者：蔡超[1] 侯玲玲[1] 胡红刚[1] 

机构地区：[1]北京交通大学理学院生命科学与生物工程研究院,北京100044

出　　处：《中国生物化学与分子生物学报》2014年第11期1069-1076,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：中央高校基本科研业务费(No.2014JBM119)~~

摘　　要：肝细胞生长因子(hepatocyte growth factor,HGF)是一种多功能的细胞因子,其生物学活性由c-Met蛋白所介导.HGF/c-Met信号通路在肿瘤生成、侵袭、转移以及肿瘤新生血管生成方面起重要促进作用.因此,HGF/c-Met信号转导通路可以作为抗肿瘤药物设计的靶点.其中,HGFα链N端447个氨基酸组成的NK4蛋白是HGF的特异性拮抗剂,它不仅通过抑制HGF/c-Met系统的信号转导发挥抗肿瘤效应;而且可以通过拮抗HGF和其它血管生成因子如成纤维细胞生长因子(fibroblast growth factors,FGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)的活性,进而抑制肿瘤新生血管生成,最终导致肿瘤细胞的凋亡.NK4的这种双重抗肿瘤功能使其成为一类很有前景的新型抗肿瘤药物.本文就NK4对肿瘤的抑制作用及其机制的研究进展进行综述.Hepatocyte growth factor( HGF) is a multifunctional cytokine to bind c-Met receptor. HGF /c-Met signaling plays an important role in tumorigenesis,tumor invasion,metastasis and angiogenesis.Thus,HGF /c-Met was proposed as a target for anti-tumor drug design. As a competitive antagonist against HGF,NK4 consists of 447 amino acids which are identical to the N-terminal of HGFα chain.NK4 inhibits tumor angiogenesis induced by vascular endothelial cell growth factor and basic fibroblast growth factor to promote the apoptosis of tumor cells. Here,we reviewed the anti-tumor effect of NK4 and the investigation of the underlying mechanisms.

关 键 词：NK4 肝细胞生长因子(HGF) 抑制肿瘤 血管生成 

分 类 号：Q813[生物学—生物工程]