接头蛋白Crk与肿瘤  

The Roles of Adaptor Protein Crk in Cancer

作　　者：田玉瑶 刘淑清[2] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京100191 [2]大连医科大学生物化学教研室,辽宁大连116044

出　　处：《中国生物化学与分子生物学报》2014年第11期1092-1097,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81272186)资助项目~~

摘　　要：Crk是一种重要的细胞内信号接头蛋白,含有SH2和SH3结构域,在信号传递过程中不仅承上启下,对信号强度还有着调控作用.迄今主要发现了4种Crk分子,即v-Crk、CrkⅠ、CrkⅡ和CrkL(Crk-Like).CrkⅡ和CrkL在分子结构上具有高度同源性,但对信号分子却具有不同的偏好性,从而体现出功能差异.本文就接头蛋白Crk的结构、Crk与相互作用蛋白质的作用机制以及与肿瘤的发生发展关系进行了阐述.Crk, as an important signaling intracellular adaptor protein, contains a SH2 and a SH3 domain. Not only does Crk connect with up- and down-stream effeetors, but also it regulates the signal intensity in the signal transduction process. So far, there are four main Crk molecules： v-Crk, Crk Ⅰ , Crk Ⅱ and CrkL （Crk-Like）. CrkL and Crk Ⅱ are highly homologous. However, they prefer to interact with different signaling factors, resulting in distinct functions. This review focuses on the structure of Crk,the mechanisms involved in Crk interaction and roles of Crk in carcinogenesis.

关 键 词：CRK Crk相关信号分子 接头蛋白 结构域 肿瘤 

分 类 号：Q71[生物学—分子生物学]