两个带呋喃悬臂不对称大环双核铜配合物的合成、结构及性质(英文)  

Syntheses,Structures and Properties of Two Unsymmetrical Bis-Furan Pendant-Armed Macrocyclic Dinuclear Cu(Ⅱ) Complexes

作　　者：程清蓉[1] 张雅[1] 周红[1] 潘志权[1] 徐志高[1] 

机构地区：[1]武汉工程大学,武汉430074

出　　处：《无机化学学报》2014年第11期2591-2600,共10页Chinese Journal of Inorganic Chemistry

基　　金：国家自然基金(No.21301131,51374158);湖北省自然基金(No.2013CFB313)资助项目

摘　　要：合成并表征了2个不对称大环双核铜配合物[Cu2(L1)Cl2]·CH3CN(1)和[Cu2(L2)Br2]·CH3CN·H2O(2)。配合物与CT-DNA的作用通过紫外-可见光谱,粘度实验,圆二色谱和凝胶电泳实验进行了研究。紫外-可见光谱的结果表明配合物与DNA的结合常数分别为6.2×105和7.2×105,圆二色谱的实验表明配合物能与DNA较好的结合,粘度实验表明配合物与DNA的结合为非典型的插入模式,凝胶电泳实验显示配合物通过氧化机理对DNA有较强的切割活性。Two unsymmetrical macrocyclic dinuclear copper complexes [Cu2（L1）Cl2]·CH3CN（1） and [Cu2（L2）Br2]·CH3CN·H2O（2） [H2L was derived from the condensation between 1,6-bis（2-furyl）-2,5-bis（5-X-2-hydroxy-3-formylbenzyl）-2,5-diazahexane（X =Cl or Br）and 1,3-diaminopropane] have been synthesized and fully characterized. The interactions of these complexes with calf thymus-DNA were studied by UV-Vis, viscosity experiment,CD spectroscopic and agarose gel electrophoresis. Absorption spectroscopic investigation reveals that1 and 2 can intercalate into CT-DNA, with binding constants of 6.2 ×105and 7.2 ×105, respectively. The appearance of increased CD bands near 246 and 278 nm gives evidence for effective complexes DNA binding.The viscosity studies indicate that the binding mode of the complexes belong to an unclassical intercalative mode.The agarose gel electrophoresis studies show that the complexes display effective DNA cleavage activity in the absence of any external agents via oxidative mechanism. CCDC： 963138, 1; 963139, 2.

关 键 词：大环配合物 圆二色谱 DNA切割 结合常数 氧化机理 

分 类 号：O614.121[理学—无机化学]