急性心肌梗死患者胆红素、CCR1、肌钙蛋白I和IL-6的检测  

Detection of bilirubin, CCR1, troponin I and IL-6 in patients with acute myocardial infarction

作　　者：康邦国 毛玉忠 

机构地区：[1]徐州市中医院,江苏徐州221000

出　　处：《细胞与分子免疫学杂志》2014年第11期1198-1200,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(30800446)

摘　　要：目的检测血清胆红素、C-C趋化因子受体1(CCR1)、血清肌钙蛋白I和白细胞介素6(IL-6)在急性心肌梗死(AMI)患者血浆中的水平。方法采用重氮法检测AMI组(65例)和正常对照组(65例)血清总胆红素(TBIL)及直接胆红素(DBIL)水平,ELISA检测血浆CCR1水平;化学发光法分别测定2组血清肌钙蛋白I水平,放射免疫分析法检测IL-6的水平。结果与正常对照组相比,AMI组TBIL为(15.07±2.87)μmol/L、IBIL为(9.32±4.58)μmol/L,低于对照组[TBIL(20.15±3.26)μmol/L、IBIL(14.48±3.90)μmol/L](P<0.05);AMI组CCR1、肌钙蛋白I、IL-6分别为(3.76±0.85)ng/mL、(15.88±2.43)U/mL、(207.60±23.94)U/mL,显著高于对照组[CCR1(0.66±0.19 ng/mL)、肌钙蛋白I(0.33±0.07)U/mL、IL-6(103.55±16.86)U/mL](P<0.05)。结论 AMI患者血清胆红素水平降低、而CCR1、肌钙蛋白I、IL-6水平升高。Objective To detect the levels of plasma C-C chemokine receptor type 1（ CCR1）,serum total bilirubin（ TBIL）,troponin I and interleukin-6（ IL-6） in acute myocardial infarction（ AMI） patients. Methods AMI group and control group respectively contained 65 samples. Diazo was used to detect the levels of serum TBIL,direct bilirubin（ DBIL） and indirect bilirubin（ IBIL）. ELISA was used to detect the level of CCR1. Troponin I and IL-6 were detected by chemiluminescence analysis and radioimmunoassay,respectively. Results The levels of TBIL [（ 15. 07 ± 2. 87） μmol /L] and IBIL [（ 9. 32 ±4. 58） μmol /L]were significantly lower in AMI group than in control group [TBIL（ 20. 15 ± 3. 26） μmol /L,IBIL（ 14. 48 ±3. 90） μmol /L]（ P〈0. 05）. However,the levels of CCR1,troponin I and IL-6 [（ 3. 76 ± 0.85） ng/mL,（ 15. 88 ± 2. 43） U/mL,（207.60±23.94） U/mL]in AMI group were significantly higher than those in control group [CCR1（ 0. 66 ±0. 19） ng/mL,troponin I（ 0. 33 ± 0. 07） U /mL,IL-6（ 103. 55 ± 16. 86） U /mL]（ P〈0. 05）. Conclusion The levels of CCR1,troponin I and IL-6 were increased and the level of serum bilirubin was decreased in AMI patients.

关 键 词：急性心肌梗死 血清胆红素 C-C趋化因子受体1 肌钙蛋白I 白细胞介素6 

分 类 号：R542.22[医药卫生—心血管疾病] R392.12[医药卫生—内科学]