口服与外用普萘洛尔治疗婴幼儿草莓状血管瘤疗效比较  

Comparison of oral and topical propranolol in the treatment of infantile strawberry hemangiomas

作　　者：于庆平[1] 李航[1] 于海霞[1] 王培培[1] 牛静静[1] 

机构地区：[1]山东省菏泽市立医院烧伤整形外科,菏泽274013

出　　处：《中国麻风皮肤病杂志》2014年第11期671-673,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:评价口服和外用普萘洛尔治疗婴幼儿血管瘤的有效性和安全性。方法:42例血管瘤患儿随机分为A、B两组(每组21例),A组口服1.5 mg/(kg·d)普萘洛尔,B组局部外用1%普萘洛尔软膏,日3次。治疗结束后随访6个月评价疗效。结果:A组12例效果优(57.1%),B组5例效果优(23.8%),两组比较有显著性差异,(P<0.05),两种方法均未出现严重的副作用。结论:口服普萘洛尔的疗效好于局部外用,但对于口服药物不能耐受的病例可选择外用普萘洛尔软膏。Objective：To compare the efficacy and safety of oral and topical propranolol in the treatment of infantile hemangiomas.Methods：Fourty-two patients were randomly divided into A group and B group：21 patients in each group.The patients in A group were treated with oral propranolol,1.5 mg/（kg· d）.The patients in B group were treated with 1％ propranolol ointment three times a day.The therapeutic efficacy and safety were assessed 6 months after treatment.Results：The result of the treatment was assessed as excellent in 12 patients （57.1％） in A group and 5 patients in B group （23.8％）.The difference in the two groups was significant （P＜0.05）.There was no severe side effects in the two groups.Conclusion：Oral propranolol is more effective than topical propranolol.Topical propranolol can be used in patients who can not tolerate the adverse effect of oral administration.

关 键 词：婴幼儿血管瘤 普萘洛尔 口服 外用 

分 类 号：R739.5[医药卫生—肿瘤]