T细胞亚群的生物学特性及临床应用进展  

Biological characteristics and clinical application of T cell subsets

作　　者：刘超 徐志国 杨旭巍 盛小琦 薛飞 贡波 闫铭杰[1,2,3] 

机构地区：[1]协和华东干细胞基因工程有限公司 [2]浙江省脐带血造血干细胞库,浙江湖州313001 [3]中国医学科学院血液学研究所,天津300020

出　　处：《转化医学杂志》2014年第6期377-380,共4页Translational Medicine Journal

摘　　要：细胞免疫治疗技术作为一项新的治疗手段,近年来在临床上相对传统疗法发挥了其特有的优势,已逐渐成为研究的热点。T细胞作为免疫细胞的重要组成部分,已在细胞治疗领域得到越来越广泛的应用。作者对辅助型T细胞、细胞毒性T细胞和调节性T细胞3类亚群的作用机制与临床应用进行综合评述,并对树突状细胞-细胞因子诱导的杀伤细胞、自然杀伤T细胞、γδT细胞、CD3单克隆抗体激活的杀伤细胞4种T细胞亚群在肿瘤治疗领域的应用进行详细比较。随着医学免疫学、细胞生物学及病理生理学的发展,细胞免疫治疗将发挥其更为重要的作用。Cellular immune therapy as a new treatment,play its unique clinical advantages to traditional therapy in recent years. It has gradually become the research hot spot. T cells as an important part of the immune cells,have been widely used in the field of cell therapy. In this paper,we give a comprehensive review on the mechanism and clinical application of 3 classes of T-cell subgroup,i. e. assistive T calls,cytotoxic T cells and regulatory T cells,and 4 types of commonly used cells in the field of tumor treatment,i. e. dendritic cells-cytokine-induced killer cells,natural killer T cells,gamma delta T and CD3 AK cells. With the development of medical immunology,cell biology and pathophysiology,cellular immune therapy will play an important role.

关 键 词：T细胞 树突状细胞-细胞因子诱导的杀伤细胞 自然杀伤T细胞 ΓΔT细胞 CD3单克隆抗体激活的杀伤细胞 免疫治疗 

分 类 号：R392.12[医药卫生—免疫学]