白种人蛋白酪氨酸磷酸酶非受体型22基因1858C/T多态性与类风湿关节炎易感性的meta分析  

PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis susceptibility in Caucasian population:a meta-analysis

作　　者：汤国平[1] 胡亮[1] 张清华[1] 

机构地区：[1]浙江大学医学院附属义乌医院

出　　处：《浙江大学学报（医学版）》2014年第4期466-473,共8页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的：探讨蛋白酪氨酸磷酸酶非受体型22（PTPN22）基因1858C／T多态性与类风湿关节炎（RA）易感性的关系。方法：检索中国生物医学文献数据库、万方医学数据库、PubMed数据库，收集有关PTPN22 1858C／T多态性与RA易感性相关的研究报告，运用meta分析方法计算不同遗传模型下的比值比（OR）值及其95％可信区间（CI）。同时进行异质性分析、亚组分析和发表偏倚检验。结果：有32篇文献纳入meta分析（40个病例对照），包括25059例RA患者和25466例对照，选入文献无发表偏倚性。meta分析结果显示：P11PN22 1858C／T多态与RA发生相关（OR=1．606，95CI％=1．518～1．699，P〈0．001）。分层分析显示，1858C／T多态是白种人罹患RA风险等位（OR=1．612，95％CI=1．544—1．683，P〈0．001），而在亚裔人群中该位点未发生突变（或者突变频率极低）。PTPN22 1858C／T多态与类风湿因子（RF）、抗环瓜氨酸肽抗体（ACCP）有相关性。结论：PTPN22 1858C／T多态的T等位是白种人的风险等位，RF、ACCP均阳性的RA患者携带1858T等位的概率大于RF、ACCP均阴性的RA患者。Objective： To investigate the association of 1858C/T polymorphism of protein tyrosine phosphatase nonreceptor type 22 （PTPN22） and rheumatoid arthritis （RA） susceptibility. Methods： CMB, wanfang （Chinese） and PubMed databases were searched to get the studies on the association between 1858C/T polymorphism and RA susceptibility, and odds ratio （OR） and 95% confidential interval （CI） were calculated under different genetic models. Then heterogeneity, stratified analysis, and publication bias test were conducted in the study. Results： A total of 32 studies （40 separate comparisons） with 25 059 RA patients and 25 466 controls were included in this meta-analysis. No evidence for publication bias was found in these studies. Meta- analysis showed an association between PTPN22 1858C/T polymorphism and RA （OR =1. 606, 95% CI. 1.518-1. 699,P 〈0. 001 ）. When stratified by ethnicity, T allele of PTPN22 1858C/T polymorphism was a risk allele in Caucasian （ OR = 1. 612, 95% CI： 1. 544-1. 683 ,P 〈 0. 001 ） ; however, the polymorphism was not detected in Asians （or allele frequencies was extremely low）. PTPN22 1858C/T polymorphism was associated with rheumatoid factor （RF） and anti-cyclic citrullinated peptide antibody （ACCP）. Conclusion： T allele of PTPN22 1858C/T polymorphism is associated with RA susaptibility in Caucasians. PTPN22 1858C/T polymorphism is significantly more prevalent in RF-positive or ACCP-positive patients than in RF-negative or ACCP- negative patients.

关 键 词：关节炎 类风湿 蛋白酪氨酸激酶类/遗传学 多态性 单核苷酸 疾病易感性 META分析 欧洲大陆世系人群 

分 类 号：R593.22[医药卫生—内科学]