心脏死亡器官捐献供肾的缺血再灌注损伤  

Donation after cardiac death and renal ischemia reperfusion injury

作　　者：季曙明[1] 陈劲松[1] 

机构地区：[1]南京军区南京总医院国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2014年第5期486-490,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：接受心脏死亡器官捐献(DCD)供肾受者移植肾功能延迟恢复(DGF)发生率明显高于传统尸体供肾,其根本原因是DCD供肾缺血再灌注损伤(IRI)。最近研究发现DCD供者体内补体C3a和C5a活化与供肾IRI密切相关,该研究将完善对C3a和C5a活化在DCD供肾IRI中作用机制的认识,并为DCD供肾IRI的防治寻找新的靶点。It has been reported that the delayed graft function （DGF） incidence of donation after cardiac death （DCD） donor renal transplantation was significantly higher than that of traditional eadaveric donor, the fundamental reason is renal isehemia reperfusion injury （IRI） in DCD. Recent studies have found that C3a and C5a activation in the DCD is closely related to renal ischemia reperfusion injury. This paper will review the recent researches on the pathogenesis of C3a and C5a activation in the role of the DCD renal IRI for finding a new therapy trarget in the management of C3a and C5a activation in renal IRI of DCD.

关 键 词：肾移植 心脏死亡器官捐献 缺血再灌注损伤 机制 

分 类 号：R699.2[医药卫生—泌尿科学]