人脐带间充质干细胞的作用:细胞移植、免疫调节及充当基因治疗靶细胞  

Role of human umbilical cord mesenchymal stem cells: cell transplantation, immuoregulation and target cells

作　　者：阮光萍[1] 姚翔[1] 刘菊芬[1] 舒帆[1] 何洁[1] 杨建勇[1] 庞荣清[1] 潘兴华[1] 

机构地区：[1]解放军成都军区昆明总医院干细胞工程实验室,云南省昆明市650032

出　　处：《中国组织工程研究》2014年第41期6714-6718,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(31172170);国家重点基础研究发展计划(973计划)(2012CB518106);云南省高新技术产业发展专项(201204);国家支撑计划(2014BAI01B01)资助的课题~~

摘　　要：背景:脐带作为分娩废弃物,来源广泛,取材方便,不受任何伦理及法理的限制,因此人脐带来源间充质干细胞的发现突破了其他间充质干细胞来源的所有限制。目的:综述人脐带来源间充质干细胞在软骨疾病、神经胶质瘤、缺血脑损伤、肺疾病、肝疾病和心肌梗死疾病模型中的应用情况。方法:由第一作者在2014年3月检索了PUBMED数据库和万方数据库,检索词为Human umbilical cord mesenchymal stem cells,disease models,cell therapy,以及人脐带间充质干细胞,动物模型,细胞治疗。共查到相关文献73篇,根据纳入标准选择35篇文献纳入研究。结果与结论:人脐带来源间充质干细胞有相似于骨髓来源间充质干细胞的多系分化能力。对比骨髓间充质干细胞,人脐带来源间充质干细胞显示出更低的免疫原性。人脐带来源间充质干细胞对软骨疾病、神经胶质瘤、缺血脑损伤、肺疾病、肝疾病和心肌梗死动物模型都有一定的治疗效果,证明人脐带来源间充质干细胞可进行细胞移植治疗多种疾病。BACKGROUND：Umbilical cord as childbirth waste has wide variety of sources and can be easily obtained, without any ethical and legal restrictions. Therefore, human umbilical cord mesenchymal stem cells break al the restrictions originated from other sources of mesenchymal stem cells. OBJECTIVE：To review the application of human umbilical cord mesenchymal stem cells in cartilage diseases, neuroglioma, ischemic brain injury, lung disease, liver disease and models of myocardial infarction. METHODS：The PubMed and Wanfang databases were searched by the first author using the keywords of“human umbilical cord mesenchymal stem cells, disease models, celltherapy”in English and Chinese, respectively. Seventy-three articles were searched and final y, 35 articles were included in result analysis. RESULTS AND CONCLUSION：Human umbilical cord mesenchymal stem cells have multilineage differentiation capacity similar to bone marrow mesenchymal stem cells. Compared with bone marrow mesenchymal stem cells, human umbilical cord mesenchymal stem cells have lower immunogenicity. Human umbilical cord mesenchymal stem cells show certain curative effects on cartilage disease, neuroglioma, ischemic brain injury, lung disease, liver disease and myocardial infarction, indicating that human umbilical cord mesenchymal stem cells can be used for celltransplantation to treat various diseases.

关 键 词：干细胞 脐带脐血干细胞 人脐带间充质干细胞 疾病模型 细胞治疗 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]