小体积肝移植动物模型的建立  

Establishment of Small-for-size Liver Transplantation Anima Model

作　　者：李来邦[1,2] 陈奕明[1,2] 张升宁[1,2] 高杨[1,2] 任刚[1,2] 张春平[1,2] 

机构地区：[1]昆明医科大学附属甘美医院 [2]昆明市第一人民医院肝胆胰科,云南昆明650031

出　　处：《昆明医科大学学报》2014年第11期31-34,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学联合专项基金资助项目(2010CD213)

摘　　要：目的模拟建立大鼠40%小肝移植大鼠动物模型.方法通过肝周骨骼化去神经效果解剖,原位灌注和肝切除术建立大鼠原位40%小肝移植动物模型.结果 40%小肝原位部分肝移植1 d生存率为90.0%(18/20),2 d生存率为85.5%(17/20),4 d生存率为65.0%(13/20),7 d生存率为60.0%(12/20).结论通过技术改进,提高了手术成功率及模型的稳定性,成功建立小肝移植大鼠动物模型.Objective To establish 40% small-for-size liver transplantation animal model in rats. Methods Elaborate anatomical technique in peri-hepatic tissue, especially in hepatic artery and portal vein, orthotopic perfusion and partial liver resection were used to establish small-for-size liver transplantation animal model in rats. Results The postoperative survival rate of rats accepted small-for-size liver transplantation was 90% （18/20） , 85.5% （17/20）, 65% （13/20） and 60% （12/20） in day-l, -2, -4 and-7, respectively. Conclusion By technological improvement, the small-for-size liver transplantation model in rats had been established successfully, and the successful rate and model stability had been improved in our experiments.

关 键 词：动物模型 肝移植 小肝综合征 

分 类 号：R617[医药卫生—外科学]