血尿酸及胆红素水平对慢性心衰患者病情进展的判断意义  

Significance of Serum Uric Acid and Bilirubin Level in Patients with Chronic Heart Failure

作　　者：杨博[1] 张再伟[2] 邵靓[2] 

机构地区：[1]首都医科大学附属北京康复医院心肺康复中心,北京100144 [2]西安交通大学医学院第一附属医院心内科,陕西西安710061

出　　处：《昆明医科大学学报》2014年第11期48-50,共3页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81300115)

摘　　要：目的探讨血尿酸及胆红素水平对慢性心衰患者病情进展的判断意义.方法选择慢性心衰患者124例,根据NYHA心功能分级标准进行分级后分别检测血尿酸、胆红素、NT-ProBNP、E/E'及LVEF.结果Ⅲ级患者尿酸、胆红素、NT-ProBNP较Ⅱ级患者均出现显著性升高,差异有统计学意义(P<0.05),Ⅳ级患者较Ⅱ、Ⅲ级患者尿酸、胆红素、NT-ProBNP均出现显著性升高,差异有统计学意义(P<0.05).Ⅲ级患者LVEF、E/E'较Ⅱ级患者均出现显著性变化,差异有统计学意义(P<0.05),Ⅳ级患者LVEF较Ⅱ级患者差异有统计学意义(P<0.05),E/E'较Ⅱ、Ⅲ级患者均出现显著性升高,差异有统计学意义(P<0.05).尿酸及胆红素分别与NT-ProBNP、E/E'显著正相关(P<0.05).结论血尿酸及胆红素与心功能相关指标密切相关,对其水平检测有助于明确慢性心衰的进展.Objective To explore the significance of serum uric acid and bilirubin levels in patients with chronic heart failure. Methods 124 patients with chronic heart failure were selected, and they were graded according to the NYHA classification grading of cardiac function. The levels of serum uric acid, bilirubin,NT-ProBNP, E/E＇ and LVEF were detected. Results Uric acid, bilirubin and NT-ProBNP of level Ⅲ patients were significantly higher than those of level Ⅱ patients（P 〈0.05）. Compared with level Ⅲ and Ⅱ patients,uric acid,bilirubin and NT-ProBNP of level Ⅳ patients were significantly increased（P 〈0.05）. There were significant changes of LVEF and E/E＇ in level Ⅲ patients compared with those in level Ⅱ（P〈 0.05）. LVEF of level Ⅳ patients was significant different from that of level Ⅱ patients（P〈 0.05）, and E/E＇ was significantly elevated compared with level Ⅱ, Ⅲ patients（P 〈0.05）. Uric acid and bilirubin showed significant positive correlations with NT-ProBNP and E/E＇（P 〈0.05）. Conclusion Serum uric acid and bilirubin were closely related with the heart function index,which are helpful to make clear the levels in chronic heart failure.

关 键 词：尿酸 胆红素 N-末端脑钠素原 心衰 

分 类 号：R541[医药卫生—心血管疾病]