索利那新治疗女性膀胱过度活动症疗效的影响因素  

Related Factors of Solifenacin in the Treatment of Female Overactive Bladder

作　　者：方桂[1] 洪莉[1] 吴德斌[1] 丁文娟[1] 洪莎莎[1] 闵洁[1] 胡鸣[1] 杨青[1] 赵杨[1] 

机构地区：[1]武汉大学人民医院妇产科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2014年第6期881-884,共4页Medical Journal of Wuhan University

基　　金：湖北省卫生厅资助项目(编号:NX2011-5);武汉市科技厅资助项目(编号:201260523178-1);武汉大学医学部协同创新项目(编号:523-266078)

摘　　要：目的:探讨索利那新对女性膀胱过度活动症(OAB)治疗成功的预测指标。方法:收集从2011年1月-2012年12月武汉大学人民医院妇Ⅱ科门诊治疗的女性膀胱过度活动症患者80例进行研究。所有患者均给予5mg索利那新,每日一次,持续12周治疗,并于开始治疗后第1,4,12周随访,根据排尿日记、尿急严重程度(USS)评分、尿动力学检查等结果评估疗效以及药物副作用情况。结果:所有80例患者都完成了这项研究,其中44例治疗有效,总有效率55%。经过12周的治疗以后,所有患者的USS评分、白天尿频次数、夜尿次数、排尿量和膀胱容量都有所改善。多因素logistic回归分析结果显示高USS评分、高最大尿流率(Qmax)和低残余尿量(PVR)都是抗毒蕈碱类药物治疗有效的预测指标。结论:高USS评分、高Qmax和低PVR患者索利那新治疗效果较好,提示USS评分、Qmax、PVR可以为索利那新治疗女性膀胱过度活动症提供指导。Objective：To explore the predictors of success treatment of solifenacin for female overactive bladder.Methods：From January,2011 to December,2012,80 cases with overactive bladder were retrospectively studied,and all patients were treated with solifenacin 5mg,once a day for 12 weeks.The patients＇ voiding diary,USS score,urodynamic test,and side-effect were studied.Results：All 80 patients completed the study,and the total effective rate was 55%（44/80）.After 12weeks＇ treatment,all patients＇ USS score,daytime urinary frequency,nocturia,voided volume and bladder capacity improved.Multivariate logistic regression analysis showed that high USS score,high maximum urinary flow rate（Qmax）and low residual urine volume（PVR）were effective predictors of success treatment of antimuscarinic drugs.Conclusion：High USS score,high Qmax and low PVR were associated with better therapeutic efficacy.The result suggests that USS score,Qmax,and PVR can serve as guidance for overactive bladder patients treated with antimuscarinic drugs.

关 键 词：索利那新 膀胱过度活动症 治疗 

分 类 号：R452[医药卫生—治疗学]