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机构地区:[1]湖北医药学院附属人民医院重症医学科,湖北十堰442000 [2]湖北医药学院附属人民医院超声影像科,湖北十堰442000
出 处:《武汉大学学报(医学版)》2014年第6期937-939,共3页Medical Journal of Wuhan University
摘 要:目的:通过分析冠状动脉粥样硬化相关因素与冠状动脉钙化积分的关系,探讨冠状动脉钙化发生机理。方法:选取湖北医药学院附属人民医院128层MDCT冠状动脉成像检查发现有冠状动脉钙化患者101例,采用传统的Agatston法计算其钙化积分,并检测所有患者血脂及肝肾功水平。通过logistic多元回归分析上述各项指标与冠脉钙化的相关性。结果:左前降支(LAD)冠脉钙化发生率最高,右冠状动脉(RCA)其次,左主干(LM)的发生率最低(P<0.01)。冠状动脉钙化积分与血浆脂蛋白a水平(P=0.002)、糖尿病(P=0.000)明显相关,冠状动脉钙化与年龄有相关性趋势,但无统计学意义(P=0.516)。分组研究显示女性糖尿病患者较女性非糖尿病钙化程度更高(63.6%比16.7%),有统计学意义(P=0.007)。结论:冠状动脉钙化积分与脂蛋白a、糖尿病有明显的相关性,脂蛋白a可能是冠状动脉钙化的一个独立预测因子,在2型糖尿病患者更为明显。Objective:To analyze the relevant factors to coronary atherosclerosis and coronary artery calcification score,and to explore the mechanism of coronary artery calcification.Methods:After128-layer MDCT coronary angiography examination,101 patients with coronary artery calcification were revealed by using the traditional method of calculating the Agatston calcium score,and blood lipids and liver and kidney function were assayed.The related factors to coronary calcification were analyzed by multivariate logistic regression.Results:Calcification was most common in the left anterior descending coronary(LAD),then in the right coronary artery(RCA),while left main(LM)calcification was the most rare(P〈0.01).Coronary artery calcium score and plasma lipoprotein(LP(a))levels(P=0.002),and diabetes(P=0.000)were significantly related to coronary artery calcification scores.Grouping studies showed that a higher degree of calcification in women with diabetes as compared with non-diabetic women(63.6%vs 16.7%,P=0.007).Conclusion:Lipoprotein(a)and diabetes are correlated to coronary artery calcium score,and lipoprotein(a)might be a independent predicator for coronary artery calcification in type 2diabetes patients.
分 类 号:R543.3[医药卫生—心血管疾病]
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