可调控纤维增强型骨组织工程支架的制备及表征  

Preparation and characteristics of the controlled and fiber-reinforced porous bone tissue engineering scaffold

作　　者：周磊[1] 潘华兴[1] 焦力刚[1] 

机构地区：[1]哈尔滨医科大学附属第二医院骨科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2014年第5期373-375,F0004,共4页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目(11551166);哈尔滨市科技创新人才研究专项资金课题(2009RFQXS222);黑龙江省卫生厅科研课题(2009-030)

摘　　要：目的：获得一种新型人工骨，使其最大限度地接近自体骨，用于修复骨缺损。方法采用粒子溶出造孔法，用棒状谷氨酸钠晶体颗粒作为造孔剂，制备磷酸钙骨水泥三维多孔支架。测定不同制孔剂质量比复合材料的孔径、孔隙率与力学性能的关系；将浸泡后的样品烘干，在研钵体中研磨成粉体用X射线衍射仪进行物相分析；对支架材料进行扫描电镜观察。结果复合支架的孔隙率可达（80.2＆#177;2.2）％，孔隙直径100～600μm；复合纤维支架材料的强度提高了3～5倍，韧性明显增强（ P＜0.05）。结论谷氨酸钠晶体作为造孔剂安全有效，加入不同质量比可调控复合支架材料的孔隙率；聚磷酸钙纤维明显改善了复合支架材料的力学性能。Objective To obtain a new type of artificial bone,which is closest to the maximum of autogenous bone for repairing bone defects.Methods Macroporous calcium phosphate ce-ments （ CPC ） scaffold was prepared by a salt-leaching method using water-dissoluble rod-shaped monosodium glutamate crystals as poregen.The relationship between the porosity and the amount of poregen was investigated.The soaked sample was dried and grinded in a mortar into a powder body for phase analysis with X-ray diffraction.The scaffold was scanned by elec-tron microscopy.Results The porosity of CPC scaffold came up to （ 80.2 ＆#177;1.2 ）% with a pore size range of 100~600μm.The compresive strength of the calcium polyphosphate （ CPP） fibers reinforced CPC scaffold increased 3 to 5 times higher than that of the CPC scaffold with-out fibers and the strain of fracture increased remarkably.Conclusion Sodium glutamate crys-tals as porous agent is safe and effective, joining different quality can control the porosity of composite scaffold materials; CPP fibers can enhance the mechanical properties of calcium phosphate cement.

关 键 词：磷酸钙骨水泥 聚磷酸钙纤维 调控 增强 支架 

分 类 号：R318.08[医药卫生—生物医学工程]