抗炎性细胞因子与抑郁症  

Anti-inflammatory Cytokines and Depression

作　　者：徐说 林文娟[1] 

机构地区：[1]中国科学院心理研究所心理健康重点实验室 [2]中国科学院大学

出　　处：《生物化学与生物物理进展》2014年第11期1099-1108,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(30770718;31170987);中国科学院知识创新工程(KSCX2-EW-J-8)资助项目~~

摘　　要：细胞因子假说是关于抑郁症发病机理的重要假说,为探讨抑郁症的发病机理和临床治疗方法提供了新方向.细胞因子分为前炎性细胞因子和抗炎性细胞因子.前炎性细胞因子与抑郁症的发病密切相关,而抗炎性细胞因子可能具有抗抑郁的作用.本文着重综述抗炎性细胞因子与抑郁症的关系.抗炎性细胞因子如白介素10、白介素1受体拮抗剂、白介素4、白介素13、转化生长因子β和脂联素等,在抑郁症中表达下降;补充外源抗炎性细胞因子则具有一定的抗抑郁作用.抗炎性细胞因子可通过拮抗前炎性细胞因子的作用,并与MAPK信号通路、神经递质和糖皮质激素相互作用而参与到抑郁症中.抗抑郁药能使抗炎性细胞因子的表达上升,这可能是药物起效的机制之一.抗炎策略在抑郁症的治疗中有重要应用前景.In recent years, the cytokine hypothesis of depression has received considerable research attention,providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10,interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-β, and adiponectin,show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall,accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression.

关 键 词：抑郁症 细胞因子 抗炎性细胞因子 抗炎作用 抗抑郁药 

分 类 号：B845[哲学宗教—心理学] R392[医药卫生—免疫学]