PIP_2信号与PIP_2的再合成  

The Specificity and Turnover of PIP_2 Signal

作　　者：徐佳曦[1] 阎向东 司曼[1] 丁杰[1] 杜雨薇[1] 张海林[1] 

机构地区：[1]河北医科大学药理教研室,石家庄050017 [2]河北省中医药科学院,石家庄050031

出　　处：《中国细胞生物学学报》2014年第11期1543-1550,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31270882);国家重点基础研究发展计划(973计划)(批准号:2013CB531302)资助的课题~~

摘　　要：磷脂酰肌醇-4,5-二磷酸(phosphatidylinositol-4,5-bisphosphate,PIP2)是一种分布在细胞膜内侧面的微量磷脂。虽然含量很低,但PIP2在细胞信号转导以及膜蛋白功能调节等方面却起着十分重要的作用。细胞膜中PIP2的含量水平呈动态平衡,在其代谢调节改变时,PIP2局部浓度的变化可影响特定蛋白的功能。该文就近二十年来针对PIP2信号和PIP2代谢调节相关的研究作一综述。Phosphatidylinositol-4,5-bisphosphate（PIP2） is a type of phosphoinositide enriched in the inner leaflet of the plasma membrane.Though PIP2 only comprises about 1% of plasma membrane phospholipids,it serves as a precursor of the second messengers,and stabilizes or activates many important membrane proteins.Cellular PIP2 levels are dynamically regulated.When the metabolic regulation of PIP2 is changed,the resulted changes in the local concentration of PIP2 will alter the function of a specific protein.This paper reviewed the researches on some aspects of PIP2 signal and its metabolic characteristics in the last two decades.

关 键 词：PIP2 PIP2信号特异性 PIP2代谢循环 

分 类 号：Q73[生物学—分子生物学]