自由基相关细胞信号传导的研究进展  

The Review on the Cell Signal Transduction Pathway Related to Free Radicals

作　　者：廖日滔 郭静科[2] 李冰洁[1] 饶平凡[2] 

机构地区：[1]福州大学生物工程研究所,福州350002 [2]中国科学院上海生命科学研究院-浙江工商大学食品营养科学联合研究中心,杭州310035

出　　处：《中国细胞生物学学报》2014年第11期1573-1583,共11页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展计划(批准号:2010CB530605);国家自然科学基金(批准号:31271859);福建省自然科学基金(批准号:2012J01133)资助的课题~~

摘　　要：自由基是带有一个孤对电子的分子,具有很强的反应性。自由基可以直接与细胞组成成分发生反应,造成细胞损伤,如通过氧化线粒体DNA和线粒体心磷脂对线粒体造成氧化损伤,从而诱导细胞凋亡。此外,自由基还能影响包括Ca2+、蛋白质磷酸化、转录因子、Bcl-2基因等多种细胞信号传导。因此,自由基产生的生物学效应范围广泛,覆盖了从生理功能调节到影响诸多疾病的病程变化。该文从自由基的产生、清除及其对多种细胞信号传导的影响等方面对相关自由基的研究进展作简要的阐述,以期获得对自由基相关细胞信号传导研究进展较为全面的了解。Free radicals are molecules with an unpaired electron,and they are strong reactive.Free radicals are able to directly react with cellular components and result in cell damage.For example,free radicals could cause oxidation damage in mitochondrion through cardiolipin peroxidation and mt DNA peroxidation,and subsequently induce apoptosis.Moreover,free radicals enable to influence the signal transduction pathways including Ca2＋,protein phosphorylation,transcription factor and Bcl-2 gene,which play most important roles in apoptosis.Therefore,free radicals produce many biological effects,ranging widely from the regulation of physiological function to the increasing destructive changes related to pathology.Here we summary the generation and elimination of free radicals and their infl uence on signal transduction pathways,and attempt to achieve more comprehensive understanding of the signal transduction by free radicals.

关 键 词：自由基 信号传导 CA2+ 蛋白质磷酸化 BCL-2 

分 类 号：Q25[生物学—细胞生物学]