窄谱中波紫外线联合地氯雷他定治疗泛发性皮炎湿疹的临床疗效观察  

Obserration on the effect of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis

作　　者：宣暄[1] 吴玲剑[1] 李秉煦[1] 

机构地区：[1]温州医科大学附属第一医院皮肤科,皮肤性病学研究所,浙江温州325015

出　　处：《温州医学院学报》2014年第10期737-739,共3页Journal of Wenzhou Medical College

摘　　要：目的:评价窄谱中波紫外线联合地氯雷他定治疗泛发性皮炎湿疹的疗效和安全性。方法:采用非随机同期对照研究方法,将114例泛发性皮炎湿疹患者分为光疗组和激素治疗组,各57例。光疗组应用窄谱中波紫外线联合口服地氯雷他定片,激素治疗组外用糠酸莫米松软膏联合口服地氯雷他定片。光疗组在治疗2、4及8周进行观察记录,激素治疗组在治疗2及4周进行观察记录。治疗结束后进行疗效评分和有效率评价。结果:在治疗2周时,2组比较,激素治疗组疗效评分中位数(3)高于光疗组疗效评分中位数(2)(P<0.05);激素治疗组有效率(为38.6%)高于光疗组(为12.3%)(P<0.05)。在治疗4周时,光疗组疗效评分为4,激素治疗组疗效评分中位数为5(P>0.05);光疗组有效率为59.6%,激素治疗组有效率为56.1%(P>0.05),2组比较差异无统计学意义(P>0.05)。光疗组2周(2)、4周(4)及8周(6)的疗效评分两两比较差异有统计学意义(P<0.05);2周(12.3%)、4周(59.6%)及8周(84.2%)的有效率两两比较差异有统计学意义(P<0.05)。结论:窄谱中波紫外线联合地氯雷他定治疗泛发性皮炎湿疹安全有效。Objective： To evaluate the clinical efficacy and safety of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis. Methods： Non-randomized concurrent control trial was used to assign 114 patients in UV-treatment group （n=57） and glucocorticoid-treatment group （n=57）. Patients in UV-treatment group received the therapy of narrow-band ultraviolet b combined with oral desloratadine. Patients in glucocorticoid-treatment group were topically applied with mometasone furoate oint- ment combined with oral desloratadine. In UV-treatment group, symptom/sign scores were evaluated at the 2th, 4th and 8th week＇s end of the treatment. In glucocorticoid-treatment group, symptom/sign scores were evalu- ated at the 2th and 4th week＇s end of the treatment. Scores and effective rates were observed after the treatment. Results： After 2 weeks of treatment, the median score of glucocorticoid-treatment group （3） and UV-treatment group （2） had significant difference （P〈0.05）; the efficient rate of UV-treatment group （12.3%） and hormones- treatment group （38.6%） had significant difference （P〈0.05）. After 4 weeks of treatment, the median score ofglu- cocorticoid-treatment group （5） and UV-treatment group （4） had no significant difference （P〉0.05）; the efficient rate of UV-treatment group （59.6%） and glucocorticoid-treatment group （56.1%） had no significant difference （P〉0.05）. In UV-treatment group, the median score had significant difference at the 2th （2）, 4th （4） and 8th （6） week＇s end of the treatment; the efficient rate had significant difference at the 2th （12.3%）, 4th （59.6%） and 8th （84.2%） week＇s end of the treatment. Conclusion： The therapy of narrow-band ultraviolet b is safe and effective in the treatment of patients with generalized eczema and dermatitis.

关 键 词：窄谱中波紫外线 地氯雷他定 皮炎 湿疹 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]