顺尔宁联合开瑞坦治疗小儿咳嗽变异性哮喘的临床观察  

Clinical observation of singulair combined with clarityne treatment of children with cough variant asthma

作　　者：王红[1] 施轶成[1] 卢琴红[2] 

机构地区：[1]杭州解放军117医院儿科,浙江杭州310013 [2]杭州市第三人民医院儿科,浙江杭州310009

出　　处：《温州医学院学报》2014年第10期765-767,共3页Journal of Wenzhou Medical College

摘　　要：目的:评价顺尔宁联合开瑞坦治疗小儿咳嗽变异性哮喘(CVA)的临床疗效,为CVA治疗提供依据。方法:60例CVA患儿随机分为对照组和观察组,每组30例。对照组采用常规治疗及糖皮质激素吸入,观察组采用顺尔宁联合开瑞坦治疗,对比2组患儿的临床疗效及不良反应。结果:观察组总有效率为86.7%,明显高于对照组的50%(P<0.05);2组患儿嗜酸性粒细胞计数均较治疗前明显减少(P<0.05),治疗后观察组明显低于对照组,其组间差异有统计学意义(P<0.05);经治疗后,观察组咳嗽缓解和消失时间均短于对照组,其组间差异有统计学意义(P<0.05);复发率方面,观察组为3.3%(1/30),明显低于对照组20.0%(6/30),P<0.05;不良反应方面,观察组发生率为13.3%(4/30),明显低于对照组的40.0%(12/30),两者比较差异有统计学意义(P<0.05)。结论:顺尔宁联合开瑞坦治疗CVA临床效果优于常规治疗及糖皮质激素吸入,且不良反应发生率低,患儿对治疗耐受性良好。Objective： To evaluate clinical efficacy of singulair combined with loratadine in the treatment of children with cough variant asthma （CVA） to provide the basis for the treatment of cough variant asthma. Methods： Sixty cases of CVA were randomly divided into control group and observation group, the control group with conventional therapy and inhaled corticosteroids, the observation group was treated with singulair combined with loratadine treatment, the clinical efficacy and adverse reaction of two groups were compared. Results： The total effective rate of observation group was 86.7%, significantly higher than that in control group 50%, P〈0.05; two groups of children with eosinophil counts were significantly decreased, P〈0.05; after treatment, the observa- tion group was significantly lower than the control group, there was a statistically significant difference between groups （P〈0.05）; the observation group after treatment, cough relieving and the disappearance time were shorter than that in the control group, there was a statistically significant difference between groups （P〈0.05）; recur- rence rate, the observation group was 3.3% （1/30）, significantly lower than that of the control group 20.0% （6/30） P〈0.05; adverse reactions, the incidence rate of the observation group was 13.3% （4/30）, significantly lower than that of the control group 40.0% （12/30） P〈0.05. Conclusion： Singulair combined with loratadine in treatment of cough variant asthma clinical effect is better than that of conventional treatment and inhaled corticosteroids, and low incidence rate of adverse reactions, good tolerance to treatment in children.

关 键 词：顺尔宁 开瑞坦 咳嗽变异性哮喘 儿童 临床观察 

分 类 号：R725.6[医药卫生—儿科]