NLRP3 炎症体在肺损伤中的研究进展  

The progress in the research of the role of NLRP3 Inflammasome in acute lung injury

作　　者：梁栋[1] 聂时南[1] 刘红梅[1] 邵旦兵[1] 唐文杰[1] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)急救医学科,南京210002

出　　处：《临床急诊杂志》2014年第11期698-701,共4页Journal of Clinical Emergency

基　　金：南京军区重点课题(No:12Z32);南京军区南京总医院青年基金课题(No:2014004)

摘　　要：Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are acute respiratory failure due to acute diffuse damage to the membrane of alveolar and capillary,having the pathological features of the noncardiac pulmonary edema and inflammation.The serious stage of ALI is ARDS.Fatality rate in the clinical goes up high.Inflammation,cell apoptosis and so on play an important role in the development of ALI.A series of pathological reaction process,mediated by signal pathways becomes the focus of research.In recent years,research shows that NLRP3 Inflammasome plays a very important role in the inflammation and the cell apoptosis of ALI.It may become a new target of the treatment of lung injury.Acute lung injury（ALI）and acute respiratory distress syndrome（ARDS）are acute respiratory failure due to acute diffuse damage to the membrane of alveolar and capillary,having the pathological features of the noncardiac pulmonary edema and inflammation.The serious stage of ALI is ARDS.Fatality rate in the clinical goes up high.Inflammation,cell apoptosis and so on play an important role in the development of ALI.A series of pathological reaction process,mediated by signal pathways becomes the focus of research.In recent years,research shows that NLRP3 Inflammasome plays a very important role in the inflammation and the cell apoptosis of ALI.It may become a new target of the treatment of lung injury.

关 键 词：急性肺损伤 NLRP3炎症体 IL-1Β IL-18 

分 类 号：R563[医药卫生—呼吸系统]