甲巯咪唑致多关节炎综合征1例  

Methimazole-induced Polyarthritis: A Case Report

作　　者：安艳华[1] 王旭东[1] 曹秋梅[1] 

机构地区：[1]首都医科大学附属北京同仁医院综合内科,北京100730

出　　处：《临床药物治疗杂志》2014年第6期60-62,共3页Clinical Medication Journal

摘　　要：1例23岁女性甲状腺功能亢进症患者接受甲巯咪唑(30mg?d-1)治疗6周后出现多发、游走性关节肿痛,查白细胞、C-反应蛋白水平升高,血沉增快,抗核抗体(ANA)1:320,抗中性粒细胞胞浆抗体(ANCA)、类风湿因子(RF)、抗链球菌溶血素O(ASO)阴性。停用甲巯咪唑1周后症状好转,1月后症状完全缓解,复查抗核抗体1:100。A 23-year-old female with hyperthyroidism developed migratory polyarthritis 6 weeks after starting therapy with methimazole （30mg daily）. Her clinical laboratory tests showed increased total white blood cel count, elevated C-reactive protein level and erythrocyte sedimentation rate and the level of antinuclear antibody （ANA） was 1：320. Test results were negative for the presence of anti-neutrophil cytoplasmic antibodies （ANCAs）, rheumatoid factor （RF） and anti-streptolysin O （ASO）. Her symptoms were improved 1 week after methimazole was withdrawn, and completely disappeared 1 month later. The test result of ANA analysis was 1：100.

关 键 词：甲巯咪唑 药物不良反应 多关节炎综合征 

分 类 号：R977.14[医药卫生—药品]