浙新霉素对皮肤癣菌的体外抗真菌活性研究  

Study on Antifungal Activities of Zhexinmycin against Dermatophytes in vitro

作　　者：张美玲[1] 鲍亚萍[1] 羊波[1] 孔繁智[1] 

机构地区：[1]浙江省立同德医院,杭州310012

出　　处：《中国药师》2014年第12期2001-2003,共3页China Pharmacist

基　　金：浙江省医药卫生科技计划项目(编号:2012KYA040)

摘　　要：目的：评价浙新霉素体外抗真菌活性。方法：采用CLSI推荐的M-38A方案测定浙新霉素对7种皮肤癣菌最小抑菌浓度（MIC）及最小杀菌浓度（MFC）。结果：浙新霉素对7种皮肤癣菌的MIC范围为0.125-2.000μg·ml^-1,MFC范围为0.250-4.000μg·ml^-1。结论：浙新霉素具有较强的抗真菌活性,能抑制和杀灭絮状表皮癣菌、红色毛癣菌、紫色毛癣菌、犬小孢子菌、须癣毛癣菌、断发毛癣菌、石膏样小孢子菌等多种皮肤癣菌。Objective： To evaluate in vitro antifungal activities of zhexinmycin against dermatophytes. Methods： The minimum inhibitory concentration（ MIC） and the minimum fungicidal concentration（ MFC） of zhexinmycin against 7 strains of dermatophytes were determined by using broth microdilution method according to CLSI M-38 A. Results： The MIC of zhexinmycin against dermatophytes was within the range of 0. 125-2. 000 μg·ml^-1. The MFC was within the range of 0. 250-4. 000 μg·ml^-1. Conclusion： Zhexinmycin shows strong in vitro antifungal effect on multiple fungi such as Epidermophyton floccosum,Trichophyton rubrum,Trichophyton violaceum,Microsporum canis,Trichophyton mentagrophytes,Trichophyton tonsurans and Microsporum gypseum.

关 键 词：浙新霉素 皮肤癣菌 体外抗真菌活性 

分 类 号：R965.1[医药卫生—药理学]