儿童自身免疫甲状腺病血清TSAb及TSBAb检测临床意义探讨  

Clinical Significance of Serum TSAb and TSBAb in Children with Autoimmune Thyroid Disease

作　　者：何娟[1] 刘戈力[2] 刘婷婷[1] 杨箐岩[2] 郑荣秀[2] 

机构地区：[1]天津医科大学研究生院,300070 [2]天津医科大学总医院儿科

出　　处：《天津医药》2014年第11期1100-1102,共3页Tianjin Medical Journal

摘　　要：目的探讨促甲状腺激素受体刺激性抗体(TSAb),促甲状腺激素受体刺激阻断性抗体(TSBAb)在儿童Graves病(GD)、桥本甲状腺炎(HT)诊治过程中的临床价值与意义。方法 88例治疗时间小于6个月的自身免疫甲状腺病(AITD)儿童分为GD 55例(GD组)和HT 33例(HT组),选择同期健康儿童38例(正常组)作为对照。分别用人血清TSAb和TSBAb ELISA试剂盒检测3组血清TSAb、TSBAb的水平,比较3组血清TSAb、TSBAb的差异,并分析血清TSAb、TSBAb之间的相关性及其与血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺素(TSH)的关系。结果 GD组血清TSAb水平高于HT组和正常组(均P<0.05);HT组血清TSBAb水平高于正常组(P<0.05);血清TSAb与TSBAb无相关性(P>0.05),血清TSAb、TSBAb与FT3、FT4、TSH均无相关性(均P>0.05)。结论 TSAb、TSBAb分别与儿童GD、HT的发病密切相关,在GD和HT的诊断和治疗中有重要的临床价值。Objective To study clinical value and significance of thyroid receptor stimulating antibody （TSAb） and thyroid stimulating-blocking antibody （TSBAb） on diagnosis and treatment for children with Graves’disease （GD） and Hashimoto’s thyroiditis （HT）. Methods Eighty-eight children with autoimmune thyroid disease （AITD） and treatment time less six months were divided into GD group （n=55） and HT group （n=33）. Thirty-eight healthy children were used as control （Normal group）. Human serum TSAb ELISA kit and human TSBAb ELISA kit were used to detect the serum TSAb and serum TSBAb in three groups. The serum levels of TSAb and TSBAb were compared between three groups. The correlation between TSAb and TSBAb, TSAb/TSBAb and free triiodothyronine three （FT3）, free thyroxine （FT4）, ultra sensitive thyroid stimulating hormone （TSH） were analyzed. Results The serum level of TSAb was significantly higher in GD group than that of HT group and Normal group （P〈0.05）. The serum level of TSBAb was significantly higher in HT group than that of Normal group （P〈0.05）. There was no significant correlation between serum TSAb and serum TSBAb （P〉0.05）. There were no significant correlation between serum TSAb, TSBAb and FT3, FT4, TSH （P〉0.05）. Conclusion TSAb and TSBAb are related to the pathogenesis of GD and HT in children. TSAb and TSBAb have an important clinical value in the diagnosis and treatment for children with GD and HT.

关 键 词：格雷夫斯病 桥本病 促甲状腺激素受体刺激性抗体 促甲状腺激素受体刺激阻断性抗体 自身免疫甲状腺病 儿童 

分 类 号：R725.81[医药卫生—儿科]