白细胞介素-6、白细胞介素-10、肿瘤坏死因子-α与冠心病关系的初步研究  

The Preliminary Study of the Relationship between IL-6,IL-10,TNF-α and Coronary Artery Disease

作　　者：董军[1] 姜华[2] 陈树涛[1] 

机构地区：[1]天津市胸科医院CICU科,300222 [2]天津市胸科医院心内一科

出　　处：《天津医药》2014年第11期1112-1113,共2页Tianjin Medical Journal

摘　　要：目的研究炎症细胞因子白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、IL-10等与冠心病(CHD)发病的关系。方法选取冠心病患者628例,同期经冠脉造影证实冠脉无狭窄的非冠心病患者540例为对照组,记录患者的资料,包括年龄、体质指数(BMI)、血糖(Glu)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标,同时用酶联免疫吸附试验法检测血清IL-6、IL-10、TNF-α等炎症因子水平。结果CHD组BMI、LDL-C、TG水平均高于对照组,而HDL-C水平低于对照组(均P<0.05)。CHD组血清IL-6、TNF-α水平均高于对照组,而IL-10低于对照组(均P<0.05)。结论血清IL-6、TNF-α参与了CHD的发生。血清IL-10有抑制炎症作用,可能对血管有保护作用。Objective To study the relationship between coronary artery disease （CHD ） and interleukin-6 （IL-6）, TNF-α and IL-10. Methods Patients with CHD were included in CHD group （n=628） and patients without CHD confirmed by coronary angiography were selected in control group （n=540） . The recorded data included age, body mass index （BMI） and serum levels of glucose （GLU）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C） and low density lipoprotein-cholesterol （LDL-C）. Meanwhile serum levels of IL-6, TNF-α, IL-10 were determined by ELISA. Results Serum levels of BMI, LDL-C, TG were higher in CHD group than those in control group（P〈0.01）. The serum level of HDL-C was significantly lower in CHD group than that in control group（P〈0.01）. Serum levels of IL-6（P〈0.05）and TNF-α（P〈0.01）were higher in CHD group than those in control group. The serum level of IL-10 was significantly lower in CHD group than that in control group（P〈0.01）. Conclusion IL-6 and TNF-αare involved in the development of CHD. IL-10 can inhibit inflammation and protect vessel integrity.

关 键 词：冠心病 白细胞介素6 白细胞介素10 肿瘤坏死因子Α 

分 类 号：R541.4[医药卫生—心血管疾病]