孕羊羊水栓塞后凝血功能的变化  

Effects of Pregnant Goat with Amniotic Fluid Embolism on Coagulation

作　　者：黄神姣[1,2] 余艳红[2] 盛超[2] 吴英[2] 

机构地区：[1]广州市妇女儿童医疗中心,广东广州510623 [2]南方医科大学南方医院,广东广州510515

出　　处：《实用妇产科杂志》2014年第11期859-862,共4页Journal of Practical Obstetrics and Gynecology

基　　金：广东省科技计划项目(编号:2003C60102)

摘　　要：目的:探讨羊水栓塞对凝血功能的影响。方法:健康孕晚期山羊16只,根据注入液体性质不同随机分为4组:原羊水组(AF组)、过滤羊水组(FAF组)、胎粪污染羊水组(MAF组)、0.9%氯化钠液对照组(NS组),每组4只。在羊水注入前、注入后30分钟、90分钟、180分钟抽取血标本动态监测纤维蛋白原(FBG)、血小板(PLT)、凝血酶原(PT)、凝血酶原指数(PTI)、血红蛋白(Hb)的变化。结果:NS组实验前后FBG、PLT、PT、PTI、Hb无明显变化。AF组、FAF组、MAF组羊水注入后PT延长,FBG、PTI明显降低,PLT明显升高,差异具有统计学意义(P<0.05)。凝血指标的改变以MAF组更为明显,Hb实验前后及组间比较差异均无统计学意义(P>0.05)。结论:羊水能激活凝血功能。羊水栓塞DIC早期,主要以FBG大量消耗,PLT聚集,PT延长为主。Objective：To explore the effects of amniotic fluid embolism on coagulation of pregnant goat. Methods：Sixteen clinical normal, healthy, pregnant goats （ Capra hircus） in the last one third of pregnancy were divided into four groups at random（ n = 4 for each group） ：raw amniotic fluid group （AF group）, filtered amniotic fluid group （ FAF group）, meconium stained amniotic fluid group （ MAF group）, or control group （ NS group）. Blood samples were taken from a femoral vein before infusion （ baseline）, and 30 min, 90 min, 180 min after infusion of amniotic fluid for FBG, PLT, PT, PTI, Hb measurement. Results： No significant changes were shown for FBG, PLT, PT, PTI, Hb level in NS group. Prolonged PT, increased PLT, lower Fbg and PTI were observed in AF, FAF and MAF group,compared to the control group（ P 〈 0.05）. The changes of the indexes were greater in MAF group;there was no significant difference on the Hb level between pre-operation and post-operation,or among these different groups（ P 〉 0. 05）. Conclusions：Amniotic fluid can activate coagulation. The changes mainly contain FBG consumption, PLT aggregation, PT prolongation in early DIC in amniotic fluid embolism.

关 键 词：羊水栓塞 凝血功能 动物模型 

分 类 号：R714.468[医药卫生—妇产科学]