皮肌炎患者血清B细胞活化因子水平与疾病活动度相关性研究  

Serum level of B cell activating factor correlates with disease activity in dermatomyositis

作　　者：彭清林[1] 张学智[1] 王艳[1] 卢昕[1] 王国春[1] 

机构地区：[1]卫生部中日友好医院风湿免疫科,北京100029

出　　处：《中华风湿病学杂志》2014年第11期743-746,共4页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（81172860）;北京市科委首都临床特色应用研究专项重点课题（Z121107001012005）

摘　　要：目的 探讨DM患者血清B细胞活化因子（BAFF）水平与疾病活动度的相关性.方法 定量ELISA方法检测61例DM患者以及25名健康对照血清BAFF浓度;利用国际肌炎组织制定的炎性肌病评价工具评估DM患者疾病活动度,并分析血清BAFF水平与DM疾病活动度的相关性.组间比较用独立Mann-WhitneyU检验,相关性分析采用Spearman秩检验.结果 横断面研究显示DM患者血清BAFF水平显著高于健康对照[（274 7±264 6）pg/ml与（832±170） pg/ml,Z=-5.492,P＜0.01];DM患者血清BAFF浓度与疾病总活动度（r=0.501,P＜0.001）、肌肉活动度（r=0.303,P＜0.05）、皮肤黏膜活动度（r=0.467,P＜0.01）呈显著正相关;血清BAFF水平升高与DM患者肺间质病变的发生具有显著相关性（x2=17.238,P＜0.01）.纵向研究同样显示DM患者血清BAFF浓度与疾病总活动度（r=0.658,P＜0.01）、肌肉活动度（r=0.307,P＜0.05）、皮肤黏膜活动度（r=0.565,P＜0.01）呈正相关.DM患者治疗后,随着疾病活动度的下降,血清BAFF水平显著降低.结论 DM患者血清BAFF水平与疾病活动度呈正相关性,血清BAFF是反映DM患者疾病活动度的生物标记物.Objective To investigate the correlation between serum levels of B cell activating factor （BAFF） and disease activity in the patients with dermatomyositis （DM）.Methods Serum BAFF levels of 61 patients with DM and 25 matched healthy controls were measured by ELISA.The results of the two groups were compared using unpaired Mann-Whitney U test and the relevance was analyzed using Spearman correlation analysis.Results Serum levels of BAFF in DM patients were significantly higher compared to healthy controls [（274 7±264 6） pg/ml 与 （832±170） pg/ml,Z=-5.492,P〈0.01].A cross-sectional assessment revealed that serum BAFF levels were positively correlated with global disease activity （r=0.501,P〈0.001）,muscle disease activity （r=0.303,P〈0.05）,and cutaneous disease activity （r=0.467,P〈0.01）.High serum BAFF levels were associated with increased incidence of interstitial lung disease （x2=17.238,P〈0.01）.The longitudinal study showed modest correlations between serum BAFF levels and global disease activity （r=0.658,P〈0.01）,muscle disease activity （r=0.307,P〈0.05）,as well as cutaneous disease activity （r=0.565,P〈0.01）.Conclusion Serum levels of BAFF correlate with disease activity in DM patients.The results of this study suggest that BAFF is a serological biomarker for DM disease activity.

关 键 词：皮肌炎 B细胞活化因子 肺疾病 间质性 

分 类 号：R593.26[医药卫生—内科学]