系统性红斑狼疮合并乳糜性胸腹腔积液四例并文献复习  

Systemic lupus erythematosus complicated with chylothorax and chylous ascites： four cases reports and review of literature

作　　者：张国华[1] 王玉华[1] 夏蓉晖[1] 赵绵松[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院风湿免疫科,100038

出　　处：《中华风湿病学杂志》2014年第11期770-773,共4页Chinese Journal of Rheumatology

基　　金：国家“十一五”科技支撑计划（2008BA159802）;首都医科大学附属北京世纪坛医院青年基金（2013.Q07）

摘　　要：目的 分析4例SLE合并乳糜性胸腹腔积液患者的临床资料,探讨两者的关系.方法 回顾性分析首都医科大学附属北京世纪坛医院2000年1月至2013年6月诊治的4例SLE合并乳糜性胸腹腔积液患者的临床资料、辅助检查及治疗转归等资料,并复习国内外文献.结果 4例患者均为女性;年龄31～47岁;SLE合并乳糜性胸腹腔积液的病程3～12个月.4例合并乳糜性胸腹腔积液患者中3例为乳糜性胸腹腔积液,1例为乳糜性胸腔积液.4例患者中3例给予糖皮质激素治疗,2例联合免疫抑制剂（环磷酰胺或环孢素A）治疗,1例患者临床症状明显缓解.结论 SLE累及淋巴系统出现乳糜性胸腹腔积液相对少见,应当引起风湿免疫科医生的重视,早期干预,积极治疗,改善患者的生活质量及预后.Objective To investigate the clinical features of 4 cases with systemic lupus erythematosus （SLE） complicated by chylothorax and chylous ascites.Methods Clinical manifestations,laboratory examinations,treatment and prognosis of 4 patients with SLE complicated by chylothorax and chylous ascites,who were admitted to our center in recent 13 years,were retrospectively analyzed.Results Four patients were female.The average age of SLE at presentation was 38 years （ranging from 31 to 47 years of age）.The average disease duration of chylothorax and chylous ascites was 6.5 months （ranging from 3 to 12 months）.Of the 4 patients,3 were complicated with chylothorax and chylous ascites,and 1 with chylothorax.Three patients were treated with corticosteroid,and 2 patients were treated combined with immuno-suppressive agents （cyclophosphamide or ciclosporin A）.Chylothorax and chylous ascites improved in 1 patient.Conclusion The clinical manifesta-tions of chylothorax and chylous ascites are relatively rare in patients with systemic lupus erythematosus,and more attention should be given to improve the quality of life of these patients.

关 键 词：红斑狼疮 系统性 乳糜 胸腹腔积液 

分 类 号：R593.241[医药卫生—内科学]