肱动脉血压正常人群测量中心动脉收缩压的意义  

The significance of measuring central aortic systolic blood pressure among normotensive crowds

作　　者：刘严[1] 齐丽彤[2] 马为[2] 杨颖[2] 孟磊[2] 张宝娓[2] 霍勇[2] 

机构地区：[1]清华大学玉泉医院急诊科,北京100049 [2]北京大学第一医院心血管内科

出　　处：《中华高血压杂志》2014年第10期935-939,共5页Chinese Journal of Hypertension

摘　　要：目的探讨肱动脉血压正常者中测量中心动脉收缩压（cSBP）的意义。方法 2010年4月至6月期间对北京市石景山区首钢地区常住居民进行调查,从中筛选肱动脉血压正常者823人（男297人,女526人）,年龄22~86（55.8±11.7）岁。根据年龄分为5个年龄组：〈40（n=60）、40~〈50（n=170）、50~〈60（n=350）、60~〈70（n=133）和≥70岁组（n=110）。采用科林HEM-9000AI脉波检测装置检测无创cSBP,测量生化指标、颈动脉内膜中层厚度（IMT）、臂踝脉搏波传导速度（baPWV）和踝臂血压指数（ABI）等指标。结果 cSBP≥140mm Hg的受试者占12.5%。女性40~〈50、50~〈60、60~〈70和≥70岁组,男性40~〈50、50~〈60和≥70岁组人群中,cSBP≥140mm Hg者的baPWV高于cSBP〈140mm Hg者（均P〈0.05）。≥70岁组cSBP≥140mm Hg者最大IMT高于cSBP〈140mm Hg者（P〈0.05）。多元线性回归分析显示,腰臀比、baPWV、空腹血糖是男性cSBP的独立影响因素（β值分别为0.13,0.35,-0.13,均P〈0.05）;baPWV是女性cSBP的独立影响因素（β=0.47,P〈0.01）。结论 〉40岁的肱动脉血压正常者的cSBP≥140mm Hg时,血管功能损害加重。Objective To assess the significance of measuring central aortic systolic blood pressure（cSBP）among normotensive crowds. Methods From April to June in 2010,a cross-sectional study was conducted in the inhabitants of Shijingshan District,Beijing. Eight hundred and twenty-tree participants with normal blood pressure and aged 55.8±11.7（range：22-86）years were included in this study,including 297 males and 526 females. All participants were divided into five groups by age〈40（n=60）,40-〈50（n=170）,50-〈60（n=350）,60-〈70（n=133）and ≥70years old（n=110）. The cSBP,biochemical parameters,intima-media thickness（IMT）,brachialankle pulse wave velocity（baPWV）,and ankle-brachial index（ABI）were measued simultaneously. Results12.5% of study participants had elevated cSBP（cSBP≥140mm Hg）. The baPWV in participants with elevated cSBP（cSBP≥140mm Hg）was consistently higher than those with lowered cSBP（cSBP〈140mm Hg）in female subgroups of aged 40-〈50,50-〈60,60-〈70and ≥70years and in male subgroups of aged 40-〈50,50-〈60,and≥70years（P〈0.05 for all）. In participants aged≥70years,the maximum IMT was higher in participants with elevated cSBP than those with lowered cSBP（P〈0.05）. Multivariable regression analysis indicated that waist-hip ratio,baPWV and fasting glucose were the independent influential factors for cSBP in male participants（β=0.13,0.35,-0.13,all P 〈0.05）,and baPWV in female participants（β=0.47,P 〈0.01）.Conclusion The normotensive crowds with cSBP≥140mm Hg aged over 40 may be accompanied by the higher degree of the functional lesion in artery.

关 键 词：血压 脉搏波传导速度 动脉硬化 

分 类 号：R544.1[医药卫生—心血管疾病]