组织声学结构定量技术对肝纤维化程度的定量研究  

Quantitative assessment of liver fibrosis by acoustic structure quantification technology

作　　者：王迪[1] 郑慧[1] 李晓金[1] 姚翀[1] 万颖[1] 李朝密 

机构地区：[1]安徽医科大学第一附属医院超声科,合肥230022

出　　处：《安徽医科大学学报》2014年第12期1780-1783,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省高校自然科学基金重点项目(编号:KJ2013A166)

摘　　要：目的采用组织声学结构定量技术(ASQ)定量评价慢性乙型肝炎患者的肝纤维化(HF)程度。方法应用装有ASQ软件的超声仪器对70例健康志愿者及80例病理明确的慢性乙型肝炎患者的肝脏进行ASQ定量分析,比较分析其χ2直方图和定量参数:众数、均值、标准差及蓝红曲线下面积比,并将以上参数与病理HF程度进行相关性分析。结果随着HF程度的增加,红蓝曲线分布由平滑、锐利变得粗糙、增宽,蓝色曲线下面积逐渐增大。红色曲线均值、蓝色曲线众数及蓝红曲线下面积比在各组间差异有统计学意义(P<0.05),红色曲线众数及蓝色曲线均值在除HF轻度组及HF中度组之间外的各组之间差异有统计学意义(P<0.05),红色曲线标准差在正常对照组与各组之间差异有统计学意义(P<0.05),蓝色曲线标准差在正常对照组和HF中度组、正常对照组和HF重度组之间差异有统计学意义(P<0.05);其中蓝红曲线下面积比与HF程度呈正相关性(rs=0.87,P<0.05)。结论 ASQ技术是一项无创性评价HF程度的新技术,通过红蓝χ2直方图及7个参数值对HF分期的评估有一定的参考价值。Objective Quantitative assessment of liver fibrosis in Chronic Hepatitis B by acoustic structure quantification technology.Methods 70 healthy volunteers and 80 patients with histologically proven chronic hepatitis B virus were examined by B-Mode ultrasound with ASQ software.The chi-square histogram and ASQ parameters （Mode,Average,SD and BR Ratio） were examined by comparative analysis,then evaluate the correlation between ASQ parameters and the pathologic result of liver fibrosis.Results With the increase of the degree of liver fibrosis,red histogram curve and blue histogram curve in the horizontal distribution was rough,broadened,the area under blue curve was much larger than the red.Red Average,Blue Mode and BR Ratio showed a statistically significant difference between each two groups （P ＜ 0.05）.Red Mode and Blue Average showed a statistically significant difference between each two groups （P ＜ 0.05） except that between mild subgroup and moderate subgroup.Red SD showed a statistically significant difference between normal subgroup and any of a subgroup （P ＜ 0.05）.Blue SD showed a statistically significant difference between normal subgroup and moderate subgroup （P ＜ 0.05）,also between normal subgroup and severe subgroup （P ＜ 0.05）.The relative gap of standardized ratio of blue and red color histogram cure area in each group was much larger than the other six indicators.Conclusion The ASQ technology is a novel,noninvasive tool.It can be used for the assessment of liver fibrosis by chi-square histogram and values of 7 parameters.

关 键 词：声学结构定量技术 肝纤维化 慢性乙型肝炎 超声检查 

分 类 号：R512.6[医药卫生—内科学] R445.11[医药卫生—临床医学]