代谢性指标与子痫前期的相关性研究  

The correlation between indicators related to metabolic syndrome and preeclampsia

作　　者：吴珍珍[1] 许晓英[1] 张丽莉[1] 

机构地区：[1]兰州甘肃省妇幼保健院中西医结合妇科,730050

出　　处：《中国妇产科临床杂志》2014年第6期523-526,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的分析子痫前期与正常孕妇代谢综合征相关指标的差异,探讨子痫前期发病中的代谢性高危因素。方法以2012年1月至12月甘肃省妇幼保健院住院分娩的116例单胎子痫前期孕妇为研究组,按随机数字表法以1∶2配对,选择同期无合并症及并发症的正常孕妇232例为对照组。收集两组孕妇的体质指数（BMI）、血压、空腹血糖（FPG）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、载脂蛋白-A1（ApoA1）和载脂蛋白-B（ApoB）进行分析。结果研究组和对照组孕前BMI分别为（25.11±4.04）kg/m2和（21.28±2.42）kg/m2,两组比较,差异有统计学意义（P〈0.01）。研究组入组时收缩压、舒张压分别为（149.29±14.02）mm Hg和（100.68±11.32）mm Hg,对照组分别为（109.29±10.34）mm Hg和（68.81±7.06）mm Hg,两组比较,差异均有统计学意义（P均〈0.01）。研究组TG和ApoB分别为（4.40±1.93）mmol/L和（1.17±0.28）g/L,对照组分别为（3.34±0.93）mmol/L和（1.01±0.21）g/L,两组比较,差异均有统计学意义（P均〈0.05）。研究组FPG、HDL-C和LDL-C、ApoA1分别为（4.15±1.62）mmol/L、（1.81±0.43）mmol/L、（3.15±1.01）mmol/L和（2.39±0.50）g/L,对照组分别为（3.95±1.13）mmol/L、（1.88±0.46）mmol/L、（2.96±0.84）mmol/L和（2.45±0.47）g/L,两组比较,差异均无统计学意义（P均〉0.05）。研究组孕前BMI≥25kg/m2者占51.72%（60/116）,高血糖占17.24%（20/116）,对照组分别为6.47%（15/232）和0,两组比较,差异均有统计学意义（P均〈0.01）。logistic回归分析显示,孕前BMI和TG与子痫前期发生的OR值分别为2.046（95%CI：1.214~3.450,P〈0.01）和1.717（95%CI：0.795~3.706,P〉0.05）。结论孕前BMI是子痫前期的危险因素。子痫前期患者中TG水平升高,而HDL-C浓度与正常孕妇无差异。Objective To research the differences of metabolic syndrome related indicators between preeclampsia and control group,and to analyze the risk factors of preeclampsia.Methods Single pregnant women who delivered in Maternal and Children Health Care Hospital of Gansu Province from January to December 2012 recruited in this study.A total of 116 pregnant cases of preeclampsia consisted research group.232 cases without the cardiovascular and endocrine complications act as control group.The pre-pregnancy body mass index（BMI）,blood pressure,fasting plasma glucose（FPG）,triglycerides（TG）,high density lipoprotein（HDL-C）,low density lipoprotein（LDL-C）,apolipoprotein A1（apoA1）and apolipoprotein B（apoB）in two groups were determined.Results 1 The following data in the two groups was siginificantly different（P〈0.01）：The prepregnancy BMI[（25.11±4.04）kg/m2vs（21.28±2.42）kg/m2];Systolic blood pressure [（149.29±14.02）mm Hg vs（109.29±10.34）mm Hg];Diastolic blood pressure[（100.68±11.32）mm Hg vs（68.81±7.06）mm Hg];TG and apoB [（4.40±1.93）mmol/L and（1.17±0.28）g/L vs（3.34±0.93）mmol/L and（1.01±0.21）g/L]（P〈0.05）.Level of FPG,HDL-C,LDL-C,and apoA1was（4.15±1.62）mmol/L,（1.81±0.43）mmol/L,（3.15±1.01）mmol/L and（2.39±0.50）g/L in research group,and was（3.95±1.13）mmol/L,（1.88±0.46）mmol/L,（2.96±0.84）mmol/L and（2.45±0.47）g/L in control group,and there was no difference in the two groups（P〉0.05）.2 The proportion of abnorminal pre-pregnancy BMI, FPG pressure was 51.72%（60/116）, 17.24%（20/116）in research group,and 6.47%（15/232）,0%（0/232）in control group（P〈0.01）.3 The risk of Metabolic Syndrome is pre-pregnancy BMI（OR=2.046,95%CI：1.214~3.450,P〈0.01）and TG（OR=1.717,95%CI：0.795~3.706,P〉0.05）.Conclusions Pre-pregnancy BMI is the risk factor of preeclampsia.The level of TG increases in preeclampsia while HDL-C is the same as normal pregnant.

关 键 词：子痫前期 代谢综合征 体质指数 甘油三酯 载脂蛋白-A1 载脂蛋白-B 

分 类 号：R714.244[医药卫生—妇产科学]