成年健康男性大脑前动脉A1段变异者Willis环形态的MR血管成像研究  

MR angiography study on morphology of the Willis＇ circle in healthy Chinese male adults with variation of A1 segment of anterior cerebral artery

作　　者：邱传亚[1] 张勇[1] 薛彩霞[1] 高敏[1] 

机构地区：[1]北京大学民航医学院民航总医院放射科100123

出　　处：《中华放射学杂志》2014年第11期897-901,共5页Chinese Journal of Radiology

摘　　要：目的 探讨大脑前动脉A1段（ACA-A1）变异者Willis环形态,以及与其他血管发育状况的关系.方法 回顾性分析2012年2月至8月进行健康体检的2 246名受试者的影像资料.所有受试者均无体格检查及生化检查异常,脑MR检查脑实质结构正常,且MRA排除动脉硬化引起的动脉狭窄.根据大脑前动脉A1段（ACA-A1）变异情况,将受试者分为变异组和对照组.利用χ^2检验比较变异组ACA-A1左右侧发育变异情况,比较变异组与对照组胚胎型大脑后动脉（FTP）的形成比例以及大脑后动脉P1段（PCA-P1）的发育情况;利用趋势χ^2检验比较变异组内不同ACA-A1发育变异程度与同侧FTP形成及PCA-P1发育变异情况的关系.结果 2 246名受试者中ACA-A1变异634例,正常1 612名.ACA-A1变异组中右侧429例、左侧205例,右侧变异多于左侧（χ^2=26.19,P＜0.01）.变异组与对照组形成FTP的比例分别为22.56％（143/634）和18.30％（295/1612）,变异组形成FTP比例较对照组高（χ^2=14.16,P＜0.01）.变异组与对照组合并PCA-P1段发育不良或缺失变异比列分别为17.35％（110/634）、14.21％ （229/1612）,变异组较对照组更易发生PCA-P1发育不良或缺失（χ^2=4.32,P＜0.05）.变异组内ACA-A1发育正常侧、轻度变异侧、发育不良侧、缺失侧形成FTP的比例分别为9.15％（58/634）、15.62％（52/333）、16.50％（34/206）、23.16％（22/95）,各变异间FTP的形成情况差异具有统计学意义（χ^2=51.12,P＜0.01）,且随着ACA-A1变异程度加重,FTP形成比例增加（χ^2=13.340,P＜0.01）.变异组内ACA-A1发育正常侧、轻度变异侧、发育不良侧、缺失侧伴有PCA-P1发育不良或缺失的比例分别为4.57％ （29/634）、12.91％（43/333）、16.02％ （33/206）、20.00％（19/95）,ACA-A1不同发育程度各组间PCA-P1发育不良或缺失变异发生差异具有统计学意义（χ^2=45.87,P＜0.01）.结论 ACA-A1变异常伴发Willis环多段血管变异,MRA�Objective To investigate the variations of multi-segments of the Willis＇ circle in cases with ACA-A1 variation.Methods Retrospective comparative analysis was applied to images of 2 246 healthy cases which were excluded from abnomalities of physical and biochemistry examination and angiostenosis caused by angiosclerosis.We divided variant group and contrast group according to variation of ACA-A1 segment.Several aspects were carried to comparison：the variation between bilateral ACA-A1 segment within the variant group was studied by χ^2 test; the proportion of FTP and developing of PCA-P1 were put into test.Finally we use trend χ^2 test to compare the variation degree of ACA-A1,ipsilateral FTP formation and PCA-P1 variation.Results Variants of ACA-A1 contains 634 cases whereas normal cases were 1 612.A prominence in variation revealed in right side of ACA-A1 （χ^2=26.19,P〈0.01） which revealed by 429 cases in right side versus 205 cases in lefi side respectively.Parallelled with contrast group,the variant group showed immensely advantages in high proportion of FTP （χ^2=14.165,P〈0.01） which indicated by variant group 22.56% （143/634）and contrast group 18.30% （295/1 612）; but crippled in PCA-P1 formation （χ^2=4.32,P〈0.05）which illustrated by proportions of by dysplasia and deficiency compared by variant group and contrast group was 17.35 % （110/634）,14.21% （229/1 612）.AC A-A 1 normal,slight variation,dysplasia and deficiency together with FTP dyformation was 9.15% （58/634）,15.62% （52/333）,16.50% （34/206）,23.16% （22/95） respectively.Within the variation group,a pattern between ACA-A1 and FTP which fluctuated simultaneously with significant statistical discrepancies （χ^2=51.117,P〈0.01; linear by linear χ^2=13.340,P〈0.01）which demonstrated by ACA-A1 normal,slight variation,dysplasia,deficiency together with FTP formation was 4.57% （29/634）,12.91% （43/333）,16.02% （33/206）,20.00% （19/95） respectively,as far as ACA-A1 variation was concerned,

关 键 词：大脑动脉环 磁共振成像 大脑前动脉 

分 类 号：R445.2[医药卫生—影像医学与核医学]