反相悬浮聚合法制备交联葡聚糖凝胶微球及其在脂质体与药物分离中的应用  

Preparation of crosslinked dextran hydrogel microspheres by inverse suspension polymerization and its application in separation of liposome and drug

作　　者：包建民[1,2] 王勇尊[1,2] 李优鑫[1] 

机构地区：[1]天津市现代药物传递及功能高效化重点实验室,天津大学药物科学与技术学院,天津300072 [2]天津奥顺达科技有限公司,天津300452

出　　处：《现代化工》2014年第11期55-58,60,共5页Modern Chemical Industry

基　　金：国家自然科学基金资助项目(21375093);高等学校博士学科点专项科研基金资助项目(20130032120081);天津大学自主创新基金资助项目(1102213)

摘　　要：以葡聚糖4万为原料,环氧氯丙烷为交联剂,甲苯为有机分散相,选用合适的分散剂,利用反相悬浮聚合的原理制备了葡聚糖凝胶微球。以微球的球形度、粒径分布范围以及吸水溶胀度等性能为衡量标准,考察了有机分散相的种类、搅拌速度、实验温度、反应时间以及分散剂的用量对制备效果的影响,确定了最优的制备条件。同时,将所制葡聚糖微球应用于脂质体与药物的分离检测,以测定其凝胶分离性能。结果表明,所制交联葡聚糖凝胶微球具有良好的球形度、分散性以及吸水溶胀性,并具有优良的凝胶过滤分离性能。The crosslinked dextran hydrogel microsphere is prepared by an inverse suspension polymerization method by using dextran 40 000 as raw material, epichlorohydrin as crosslinking agent and toluene as organic dispersed phase. The sophericity, particle size distribution and water swelling properties of the microspheres are chosen as the evaluation criterion to optimize those experimental factors, including the kind of the organic dispersed phase, stirring speed, experimental temperature,the reaction time and amount of dispersant. Meanwhile, the dextran microsphere is used for the separation of liposomes and drugs. The result indicates that the homemade microsphere has good sophericity, distribution,water swelling property and separating performance.

关 键 词：反相悬浮聚合原理 交联葡聚糖凝胶微球 分离性能 

分 类 号：TQ316.2[化学工程—高聚物工业]