NGAL测定在急性肾损伤诊断中应用的研究进展  

The Research Progress of NGAL Test in the Diagnosis of Acute Kidney Injury

作　　者：何莹[1,2] 陈安[2] 胡川闽[2] 

机构地区：[1]解放军第323医院检验科,西安710054 [2]第三军医大学临床生化教研室,重庆400038

出　　处：《医学综述》2014年第22期4044-4046,共3页Medical Recapitulate

基　　金："863"计划重点项目(2011AA02A113)

摘　　要：中性粒细胞明胶酶相关脂质运载蛋白(NGAL)存在于中性粒细胞的过氧化物酶阴性颗粒中,并在人体组织细胞中广泛分布。近年研究发现,NGAL与肾脏关系十分密切,可能参与启动肾脏发育并发挥保护肾脏的作用。众多实验室和临床研究表明,急性肾损伤(AKI)时NGAL表达明显增高并分泌释放入体液中。尤其是尿液中的NGAL水平与肾脏损伤的程度密切相关且很早就表现出来,NGAL被认为是新的有效的AKI早期生化标志物。Neutrophil gelatinase-associated lipocalin（ NGAL） presents in the peroxidase-negative granules of neutrophils,and is widely distributed in the human tissue cells. Recent studies found a very close relationship between NGAL and kidney. NGAL may initiate the development of kidney and afford kidney protection. Abundant experimental and clinical studies have shown that expression of NGAL was significantly higher during renal injury and NGAL would release into the body fluids. It is very early manifested that urine NGAL levels and the degree of kidney damage is closely related. NGAL is considered to be a new biochemical marker of acute kidney injury.

关 键 词：中性粒细胞明胶酶相关脂质运载蛋白 急性肾损伤 早期诊断 

分 类 号：R446[医药卫生—诊断学]