单核苷酸多态性在代谢综合征研究与防治中的应用  

Application of Single Nucleotide Polymorphism in the Research and Control of Metabolic Syndrome

作　　者：王羽佳(综述)[1] 陈思娇[2] 宋今丹(审校)[3] 

机构地区：[1]中国医科大学,沈阳110001 [2]中国医科大学附属第一医院老年科,沈阳110001 [3]中国医科大学医学分子生物学研究所,卫生部细胞生物学重点实验室,沈阳110001

出　　处：《医学综述》2014年第22期4155-4157,共3页Medical Recapitulate

摘　　要：单核苷酸多态性(SNP)是第三代分子标记技术,成为当今医学研究最常用的方法之一。随着遗传学、分子生物学的发展,SNP的检测和分析方法趋于多样化,并逐步深入到临床疾病的研究和防治过程中,如代谢综合征。以SNP为基础的基因芯片技术用于筛查代谢综合征快速而准确,得到广泛应用,正逐步取代传统的DNA检测。将SNP检测结果作为参数来构建代谢综合征风险预测模型,从而起到风险预测评估,指导预防疾病发生的作用。同时,代谢综合征关联基因的确定有助于治疗方案的制订。Single nucleotide polymorphism（ SNP） is the third generation of molecular marker technology,which has become one of the most commonly used methods in medical research in recent years. With the development of the genetics and molecular biology,methods of detecting and analyzing SNP tend to be diversified,and gradually apply in the process of clinical research and control of diseases,for example,the metabolic syndrome. The gene chip technology based on SNP is widely used to screen the metabolic syndrome because it＇s fast and accurate,and it is gradually replacing the traditional DNA test. Using the SNP detection results as parameters to build the metabolic syndrome risk prediction model is helpful to the risk prediction assessment and guidance of disease precaution. At the same time,the identification of metabolic syndrome associated genes contributes to the formulation of treatment plans.

关 键 词：单核苷酸多态性 代谢综合征 脂联素 基因芯片 风险预测模型 

分 类 号：R589.9[医药卫生—内分泌] R394.3[医药卫生—内科学]