父源性人类白细胞抗原与子痫前期研究进展  

Research Progress on the Correlation of Patrilineal HLA with Preeclampsia

作　　者：李玥桦 朱启英[1] 

机构地区：[1]新疆医科大学第一附属医院产科,乌鲁木齐830054

出　　处：《医学综述》2014年第22期4158-4160,共3页Medical Recapitulate

摘　　要：子痫前期是妊娠期特有的多系统疾病,是导致孕产妇及围生儿患病及死亡的主要原因之一。因胎儿体内有一半是父源性基因,着床时,父源性人类白细胞抗原侵入母体子宫蜕膜段与母体内免疫活性细胞接触,产生免疫耐受。若此免疫平衡被打破,将导致妊娠失败或病理妊娠。人类白细胞抗原是人体内最复杂的基因,具有高度的多态性,在调节母胎界面的免疫耐受方面具有关键作用。研究表明,父源性人类白细胞抗原与子痫前期的发生具有一定相关性。Preeclampsia is a typical multi-system disease during pregancy,which is one of the main causes of maternal and perinatal morbidity and mortality. As half of fetus＇ genes comes from the father,when the embryo implants,trophoblast with patrilineal HLA invades in placenta decidua and contacts with immune cells,inducing immunological tolerance. When the balance is broken,it will lead to pregnancy failure or pathologic pregnancy. HLA is the most complicated genes in human body,with the highest polymorphism. HLA is the key to maintain the maternal-fetal immune tolerance. Recent researches has shown that preeclampsia has close relationship with patrilineal HLA.

关 键 词：子痫前期 父源性人类白细胞抗原 基因多态性 

分 类 号：R714.24[医药卫生—妇产科学]