慢性肾脏疾病患者血清半乳糖凝集素-3检测的临床意义  

Serum level of galectin 3 and its clinical significance in patients with chronic kidney disease

作　　者：赖冬[1] 熊咏梅[1] 龙敏[1] 张以勤[1] 

机构地区：[1]福建省厦门市第二医院中心实验室,361021

出　　处：《重庆医学》2014年第33期4460-4461,共2页Chongqing medicine

基　　金：厦门市科技局科技计划项目(3502z20134030)

摘　　要：目的探讨慢性肾脏疾病(CKD)患者中血清半乳糖凝集素-3(Gal-3)的水平及其临床意义。方法采用ELISA检测健康对照组(34例)及CKD组(38例)中血清Gal-3水平,采用全自动生化分析仪测定肾功能,并分析其与CKD分期的关系。结果 CKD组中Gal-3血清水平(1.22±1.01)ng/mL显著低于健康对照组(3.03±2.06)ng/mL,差异有统计学意义(P<0.05);血清Gal-3水平与血清Cr、CysC水平呈负相关(P<0.05)。结论血清Gal-3水平与CKD患者肾损害程度密切相关,可作为判断CKD肾损害程度的生化指标。Objective To detect serum galectin 3 levels in patients with chronic kidney disease （CKD） and explore its clinical significance .Methods The galectin 3 levels the serum of in 38 CKD patients and 34 healthy controls were determined by ELISA . All kidney function was measured by automatic biochemical analyzer .The relation between serum galectin 3 levels and the level of kidney function was analyzed by use of t test .Results The serum galectin 3 levels in CKD and healthy controls groups were （1 .22 ± 1 .01）ng/mL and （3 .03 ± 2 .06）ng/mL ,P〈0 .05 .There was close negative correlation between serum levels of galectin 3 and Cr ,CysC（P〈0 .05） .Conclusion Serum galectin 3 of CKD patients reduces significantly and correlates with kidney function . Detecting on s galectin 3 is helpful for chronic kidney disease diagnosis and therapeutic effect evaluation .

关 键 词：半乳糖凝集素3 慢性肾脏疾病 肾功能 

分 类 号：R692[医药卫生—泌尿科学]