血浆同型半胱氨酸与B型尿钠肽对急性心肌梗死的诊断和预后价值  

Clinical value of plasma Hcy and BNP joint detection in the diagnosis and prognosis of acute myocardial infarction

作　　者：张启贵[1,2] 陈雪礼[1,2] 涂艳[1,2] 刘晓峰[1,2] 

机构地区：[1]九江市第一人民医院 [2]南昌大学附属九江医院检验科,江西九江332000

出　　处：《国际检验医学杂志》2014年第22期3015-3016,共2页International Journal of Laboratory Medicine

基　　金：九江市科技计划项目(20133801)

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)和B型尿钠肽(BNP)联合检测对急性心肌梗死(AMI)的诊断和预后价值。方法选取140例AMI患者(AMI组)及125例健康人(对照组),分别检测其血浆Hcy和BNP水平,并对结果进行分析。结果治疗前,AMI组血浆BNP[(585.24±155.37)pg/mL]和Hcy[(33.4±9.84)μmol/L]水平明显升高,与对照组比较差异有统计学意义(P<0.05)。AMI患者经治疗后血浆BNP和Hcy水平显著降低,与治疗前比较差异有统计学意义(P<0.05)。在随访期间,发生心血管事件的AMI患者血浆BNP和Hcy水平明显高于未发生心血管事件的AMI患者,差异具有统计学意义(P<0.05)。结论 BNP和Hcy可作为指导临床诊断和治疗AMI的重要指标,并可作为预测AMI患者远期康复的重要参数。Objective To explore the clinical significance of plasma homocysteine（Hcy）and brain natriwetic peptide（BNP）joint detection in the diagnosis and prognosis of acute myocardial infarction（AMI）.Methods The plasma Hcy and BNP levels of140 cases of AMI patients（AMI group）and 125 cases of healthy people（control group）were detected respectively,and the results were analyzed.Results Before treatment,the plasma BNP and Hcy levels of AMI group were（585.24±155.37）pg/mL and（33.4±9.84）μmol/L respectively,which were significantly higher than those of control group（P〈0.05）.After treatment,the plasma BNP and Hcy levels were both significantly lower than those before treatment（P〈0.05）.During the follow-up period,the plasma BNP and Hcy levels of the patients with cardiovascular events were significantly higher than the patients without cardiovascular events（P〈0.05）.Conclusion BNP and Hcy can be used as vital factors to guide clinical diagnosis and treatment of AMI,and they maybe important parameters to predict prognosis.

关 键 词：急性心肌梗死 同型半胱氨酸 B型尿钠肽 诊断 预后 

分 类 号：R542.22[医药卫生—心血管疾病] R446.1[医药卫生—内科学]