临床常用β-内酰胺类抗菌药物对果糖胺检测的干扰分析  

The analysis of β-lactam antibiotics interference in fructosamine testing

作　　者：颜巍[1] 周竞[1] 姚文娟[1] 程冉[1] 姚孝明[1] 

机构地区：[1]江苏省中西医结合医院检验科,江苏南京210028

出　　处：《国际检验医学杂志》2014年第22期3097-3098,3101,共3页International Journal of Laboratory Medicine

摘　　要：目的观察临床常用的13种β-内酰胺类抗菌药物对果糖胺检测项目的干扰情况。方法将抗菌药物用注射用水配制成系列溶液,按5%体积加入到新鲜的混合血清中,评价不同抗菌药物对果糖胺检测结果的干扰。结果头孢硫脒和替卡西林钠/克拉维酸钾的血药浓度分别达到37.5mg/L和247.5μg/mL时,开始对果糖胺的检测产生正干扰,但干扰程度与果糖胺血清浓度无关。结论头孢硫脒和替卡西林钠/克拉维酸钾对果糖胺检测结果存在干扰。Objective To evaluate the interference of 13 kinds ofβ-lactam antibiotics in fructosamine detection.Methods A series of solution of antimicrobial drugs were formulated with water for injection,and added into the mixture fresh serum volume by5%.Interfere with antimicrobial drugs on the test results of fructosamine were evaluated.Results When the blood concentrations of cefathiamidine and ticarcillin sodium/clavulanate potassium were up to 37.5mg/L and 247.5μg/mL respectively,they began to produce positive interference on fructosamine detection.However,the degree of interference was not correlated to the serum concentration of fructosamine.Conclusion Cephathiamidine and ticarcillin sodium/clavulanate potassium have positive interference on fructosamine detection.

关 键 词：头孢硫脒 替卡西林 克拉维酸 果糖胺 干扰 

分 类 号：R96[医药卫生—药理学]