贝前列素钠对老年2型糖尿病合并下肢血管病变患者血清TNF-α、sICAM-1的影响  

Beraprost sodium on patients with lower extremity vascular disease patients and serum in patients with type 2 diabetes Effects of TNF-α,sICAM-1

作　　者：周波 

机构地区：[1]湖北省中山医院药剂科,湖北武汉430032

出　　处：《中国实验诊断学》2014年第11期1779-1781,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的观察贝前列素钠对老年2型糖尿病合并下肢血管病变患者血清肿瘤坏死因子-α(TNF-α)、可溶性细胞间粘附分子-1(sICAM-1)的影响。方法选择老年2型糖尿病合并下肢血管病变患者160例,分为对照组(80例)和观察组(80例)。两组均给予常规药物控制血糖。对照组:阿司匹林肠溶片75mg,口服,qd。观察组:贝前列素钠,40μg,口服,tid;6个月。采用ELISA法检测用药前后血清TNF-α、sICAM-1。结果对照组用药前后血清TNF-α、sICAM-1无明显变化(P>0.05);而观察组用药后血清TNF-α、sICAM-1均明显低于用药前及对照组用药后水平(P<0.05)。结论贝前列素钠能明显降低老年2型糖尿病合并下肢血管病变患者血清TNF-α、sICAM-1的表达。Objective To observe the serum tumor necrosis factor-beraprost sodium on elderly patients with type 2diabetic patients with lower extremity vascular disease alpha（TNF- α）,soluble intercellular adhesion molecule-1（sICAM-1）effect.Methods 160 cases of elderly patients with type 2diabetic patients with lower extremity vascular disease,divided into the control group（80cases）and observation group（80cases）.Two groups were treated with routine drugs to control blood sugar.Control group：Aspirin Enteric-coated Tablets 75 mg,oral,qd.The observation group：beraprost sodium,oral administration of 40μg,tid.ELISA was used to detect serum TNF-α,sICAM-1before and after treatment.Results The control group before and after treatment the serum TNF-α,sICAM-1had no significant change（P〉0.05）;and the observation group after treatment,serum TNF-α,sICAM-1were significantly lower than those before therapy and control group after treatment（P〈0.05）level.Conclusion beraprost sodium has a better therapeutic effect on vascular disease in the lower limbs in aged patients with type 2diabetes mellitus,expression can significantly decrease the serum TNF-α,sICAM-1.

关 键 词：贝前列素 糖尿病 肿瘤坏死因子 可溶性细胞间粘附分子-1 

分 类 号：R587.2[医药卫生—内分泌]