苁蓉冲剂对环磷酰胺致白细胞减低症模型小鼠作用的观察  

The Effect of Congrong Granules on Leukopenia in Mice induced by Cyclophosphamide

作　　者：李得春[1] 张永梅[1] 胡同平[1] 杨玉梅[2] 乔姝[1] 张利霞[1] 杨丽[1] 彭忠忠[1] 

机构地区：[1]包头医学院第一附属医院,内蒙古包头014010 [2]包头医学院,内蒙古包头014010

出　　处：《包头医学院学报》2014年第5期9-11,共3页Journal of Baotou Medical College

基　　金：包头市科技计划项目(2011S2012-01-4)

摘　　要：目的:探讨苁蓉冲剂对环磷酰胺所致小鼠白细胞减少症的作用效果。方法:小鼠腹腔连续7 d注射环磷酰胺溶液(50 mg/kg)制成白细胞减少症模型,并用苁蓉冲剂进行灌胃,检测外周血象和T淋巴细胞亚群。结果:苁蓉冲剂可使模型小鼠外周血白细胞数、淋巴细胞数和血小板数升高,可使血红蛋白含量升高,可调节CD4+/CD8+细胞比例。结论:苁蓉冲剂可改善环磷酰胺所致白细胞减少症外周血象,调节免疫失衡。Objective：To assess the effect of Congrong granules on cyclophosphamide - induced leukopenia in mice mod-els. Methods：The leukopenia mice models were established by consecutively injecting cyclophosphamide solution（50 mg/ kg） for 7 days and gavaged with Congrong granules,with the peripheral hemogram and subgroup of T lymphatic cells detested. Re-sults：Congrong granules could increased peripheral blood leukocyte count,lymphocytes count,blood platelet count and hemoglo-bin content,with the ratio of CD4^＋ / CD8^＋ cells modulated. Conclusion：Congrong granule can improve the peripheral hemogram of leukopenia induced by cyclophosphamide and regulate the immune imbalance.

关 键 词：苁蓉冲剂 环磷酰胺 小鼠 白细胞减少症 

分 类 号：R285.5[医药卫生—中药学]