S100A4蛋白在甲状腺乳头状癌中的表达及意义  

Expressions and Clinical Significance of S100A4 Protein in Papillary Thyroid Carcinoma

作　　者：黄器伟[1] 翟娜娜[1] 徐凯[1] 

机构地区：[1]黄河科技学院医学院,河南郑州450000

出　　处：《广东化工》2014年第21期41-41,61,共2页Guangdong Chemical Industry

摘　　要：目的探讨甲状腺乳头状癌中S100A4蛋白的表达,分析其与甲状腺乳头状癌发生及淋巴结转移的关系。方法应用免疫组织化学SP法检测50例甲状腺乳头状癌组织、14例甲状腺腺瘤组织、26例结节性甲状腺肿组织和10例正常甲状腺组织中S100A4蛋白的表达。结果甲状腺乳头状癌中S100A4蛋白的阳性表达率为78.00%,明显高于甲状腺腺瘤组织、结节性甲状腺肿组织及正常甲状腺组织(P<0.05);S100A4蛋白在癌组织中的表达与甲状腺乳头状癌淋巴结转移有关(P<0.05)。结论 S100A4蛋白的高表达与甲状腺乳头状癌的发生发展和淋巴结转移密切相关,其检测有助于鉴别甲状腺良恶性病变,并预测肿瘤的发展和预后。Objective To investigate the expression of S100A4 protein in papillary thyroid carcinoma and the correlation with the occurrence and lymphatic metastasis of papillary thyroid carcinoma. Methods The immunohistochemistry S-P was used to test the different expression of S100A4 protein in tissues of 50 papillary thyroid carcinoma, 14 thyroid adenoma, 26 nodular goiter and 10 normal thyroid gland. Results The positive expression rates of S100A4 protein in papillary thyroid carcinoma was 78.00 %. It was significantly higher than it in thyroid adenoma, nodular goiter and normal thyroid gland（P〈0.05）; The expression rates of S100A4 protein in papillary thyroid carcinoma was associated with lymph node metastasis（P〈0.05）. Conclusion The over expressions of S100A4 protein was closely related with the occurrence and lymphatic metastases of thyroid carcinoma. Detection of S100A4 would help to distinguish the benign or malignant disease of thyroid gland and predict tumor development and prognosis.

关 键 词：甲状腺乳头状癌 S100A4 

分 类 号：S858.31[农业科学—临床兽医学]