老年性痴呆危险因素之间的交互作用分析  

Interaction of Risk Factors for Alzheimer's Disease

作　　者：李慧[1] 黄鹏[2] 曹飞[3] 陈宝[3] 李譞超[3] 黄河浪[2] 吴磊[2] 

机构地区：[1]南昌大学公共卫生学院,2010级南昌330006 [2]南昌大学公共卫生学院流行病学教研室,南昌330006 [3]南昌大学研究生院医学部,2012级南昌330006

出　　处：《南昌大学学报（医学版）》2014年第9期76-78,共3页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81260441)

摘　　要：目的探讨老年性痴呆(AD)危险因素之间可能存在的交互作用。方法通过病例对照研究获得老年性痴呆的主要影响因素,然后采用相加模型分析主要影响因素之间的交互作用。结果 Logistic回归分析显示,年龄(OR=1.069)、文化程度(OR=0.601)、脑血管病史(OR=3.660)、血铝水平(OR=3.739)、血硒水平(OR=0.611)为AD的主要影响因素。在对年龄进行调整后,交互作用超额相对危险度(RERI)为6.877,交互作用归因比(API)为59.52%,交互作用指数(S)为2.870。结论血铝水平和脑血管病史在AD的患病中可能存在正交互作用。Objective To explore the interaction of risk factors for Alzheimer’s disease （AD）. Methods The main risk factors for AD were obtained by case-control study and the interaction of risk factors was analyzed by additive model.Results Logistic regression analysis indicated that age （OR = 1.069）,education degree （OR = 0.601 ）,history of cerebrovascular disease （OR =3.660）,blood aluminum level （OR=3.739）and blood selenium level （OR=0.611）were the main risks factors for AD.After adjusting the influence of age,the relative excess risk due to interac-tion,attributable proportion due to interaction and synergy index were 6.877,59.52% and 2.870, respectively.Conclusion There is a synergism interaction between blood aluminum level and his-tory of cerebrovascular disease in AD.

关 键 词：老年性痴呆 影响因素 交互作用 

分 类 号：R195.4[医药卫生—卫生统计学]