米氮平与氟西汀治疗紧张性头痛伴抑郁症状对照研究  

A control study of mirtazapine vs.fluoxetine in the treatment of tension headache with depressive symptoms

作　　者：龙赟[1] 王群英[1] 毕燕君[1] 

机构地区：[1]自贡市精神卫生中心,四川自贡643020

出　　处：《临床心身疾病杂志》2014年第6期23-25,共3页Journal of Clinical Psychosomatic Diseases

基　　金：2011年自贡市科学技术重点项目（编号11S087）

摘　　要：目的 探讨米氮平与氟西汀治疗紧张性头痛伴抑郁症状患者的临床疗效和安全性.方法 将61例紧张性头痛伴抑郁症状患者随机分为两组,分别口服米氮平、氟西汀治疗,观察6周.采用视觉疼痛模拟量表、汉密顿抑郁量表、副反应量表评定临床疗效和不良反应.结果 治疗后两组视觉疼痛模拟量表、汉密顿抑郁量表评分均较治疗前显著下降（P＜0.01）;米氮平组视觉疼痛模拟量表评分治疗第4周、6周末较氟西汀组下降更显著（P＜0.05）;治疗6周末米氮平组缓解疼痛症状有效率显著高于氟西汀组（P＜0.05）.研究期间两组均未出现严重不良反应.结论 米氮平与氟西汀均能显著改善紧张性头痛伴抑郁症状患者的疼痛和抑郁症状,但米氮平缓解疼痛症状起效快,疗效显著,安全性高,优于氟西汀治疗.Objective To explore the efficacy and safety of mirtazapine and fluoxetine in the treatment of tension headache （TH） with depressive symptoms. Methods Sixty-one TH patients with depressive symptoms were randomly divided into two groups taking orally mirtazapine and fluoxetine respectively for 6 weeks. The clinical efficacies were assessed with the Visual Analogue Scale （VAS） and Hamilton Depression Scale（HAMD）and adverse reactions with the Treatment Emergent Symptom Scale（TESS）. Results After treatment, the VAS and HAMD scores of both groups lowered more significantly compared with pretreatment （P〈0.01）; the VAS scores lowered more significantly in mirtazapine than fluoxetine group at the end of the 4th and 6th week （P〈0.05）. Adverse reactions of both groups were mild. Conclusion Both mirtazapine and fluoxetine could significantly improve pain and depressive symptoms of TH patients with depressive symptoms, but the former takes effects more rapidly and has an evident effect and higher safety compare with the latter.

关 键 词：紧张性头痛 抑郁症状 米氮平 氟西汀 视觉疼痛模拟量表 汉密顿抑郁量表 副反应量表 

分 类 号：R441.1[医药卫生—诊断学] R749.4[医药卫生—临床医学]