RGC-32与细胞周期调控  

RGC-32 involving in cell cycle regulation

作　　者：刘华杰[1] 黄文彦[1] 

机构地区：[1]上海市儿童医院上海交通大学附属儿童医院肾脏风湿科,200040

出　　处：《国际儿科学杂志》2014年第6期598-600,共3页International Journal of Pediatrics

基　　金：国家自然科学基金项目（81370813）;上海市卫生局优秀学科带头人项目（XBR2011010）

摘　　要：RGC-32（response gene to complement-32）是一种重要的补体应答分子,同时也参与了许多其他生物学功能.近来的研究发现RGC-32为细胞周期G2/M检测点关键调控分子,在细胞周期精细调控过程中发挥重要作用,并参与细胞增殖分化、再生修复、炎症反应、肿瘤形成等多种生物学过程.但RGC-32对细胞周期确切的调控机制有待阐明.该文就RGC-32基因及其生物学功能、细胞周期调控以及两者之间的调控关系等作一简要综述.As one of the important response gene to complement,response gene to complement-32 （RGC-32） simultaneously involves in many other biological functions.Recent studies have shown that RGC-32 was one of the critical regulatory factors at the G2/M check point in the cell cycles and involved in the cell cycle regulation.The expression products of RGC-32 gene play the key roles in cell proliferation,differentiation,inflammation,tumor metastasis and other processes.However,it has not been clarified in its biological mechanisms of regulation in cell cycle.This article takes a brief review about RGC-32 on its gene structure,biological functions,regulation of cell cycle,and the relationship of cell cycle regulation which involves in RGC-32.

关 键 词：RGC-32 细胞周期调控 G2/M检测点 细胞增殖分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]