硒酵母对2型糖尿病患者血清C肽水平的影响  

Effect of selenium yeast on serum level of C-peptide in patients with type 2 diabetes mellitus

作　　者：张高芝 黄晓燕[1] 林宏献[1] 吴玉玲[1] 

机构地区：[1]温州医学院附属乐清医院内分泌科,浙江乐清325600

出　　处：《实用药物与临床》2014年第11期1417-1419,共3页Practical Pharmacy and Clinical Remedies

基　　金：温州市科技局计划项目(2013B43)

摘　　要：目的观察硒酵母对2型糖尿病(T2DM)患者血清C肽水平的影响。方法选取120例T2DM患者,依据随机原则分为:对照组(60例,予以常规降糖等正规治疗措施)和治疗组(60例,在常规治疗基础上加用硒酵母片治疗,至少应用3个月)。治疗1年后比较治疗前后两组患者的空腹C肽水平、餐后2 h C肽、餐后2 h C肽较空腹C肽倍数、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)及餐后2 h血糖(PPG)差异。应用Pearson相关性分析分别评估硒酵母疗程与空腹C肽水平、餐后2 h C肽的相关性。结果治疗前两组上述各项指标差异均无统计学意义(P>0.05)。治疗后与对照组相比,治疗组的空腹C肽水平、餐后2 h C肽、Hb A1c、FPG与PPG显著改善(P<0.05),而两组餐后2 h C肽较空腹C肽倍数比较差异无统计学意义(P>0.05)。硒酵母疗程与空腹C肽水平(r=0.613,P=0.021)、餐后2 h C肽(r=0.574,P=0.038)均存在正相关。结论硒酵母可提高T2DM患者空腹及餐后2 h C肽水平,改善血糖控制程度。Objective To analyze the effect of selenium yeast on serum level of C-peptide in patients with type 2 diabetes mellitus（T2DM）. Methods A total of 120 patients with T2DM were randomly divided into two groups,control group（n=60）received regular hypoglycemic therapy,treatment group（n=60）received selenium yeast therapy based on regular hypoglycemic therapy and the course of selenium yeast therapy at least 3 months. After one year treatment,the indexes of fasting C-peptide level,2 h post-prandial C-peptide level,the ratio of 2 h post-prandial C-peptide to fasting C-peptide,HbA1c,fasting plasma glucose（FPG）and 2 h post-prandial plasma glucose（PPG）were compared between the two groups. The relationships of the course of selenium yeast to fasting C-peptide level and 2 h post-prandial C-peptide level were analyzed by Pearson correlation analysis. Results The above indexes before therapy had no significant difference between the two groups（P〉0. 05）. Compared with control group,the indexes of fasting C-peptide level,2 h post-prandial C-peptide level,HbA1c,FPG and PPG in treatment group were more perfect（P 〈0. 05）,and there was no significant difference in the ratio of 2 h post-prandial C-peptide to fasting C-peptide（P 〉0. 05）. The positive relationships of the course of selenium yeast to fasting C-peptide level（r=0. 613,P=0. 021）and 2 h post-prandial C-peptide level（r=0. 574,P =0. 038）were confirmed by Pearson correlation analysis. Conclusion The selenium yeast can increase the serum levels of fasting and 2 h post-prandial C-peptide,and also improve the de-gree of glycemic control in patients with T2DM.

关 键 词：硒酵母 2型糖尿病 血清C肽 相关性分析 

分 类 号：R587.1[医药卫生—内分泌]