C_(21) Steroidal Glycosides from Acidic Hydrolysate of Cynanchum otophyllum  

作　　者：Yi-bin Zhao Quan-shui Fan Gui-li Xu Zi-liang Feng Xiao-jiang Hao 

机构地区：[1]Postdoctoral Programme of Center for Disease Control and Prevention,Chinese PLA Chengdu Military Command [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences

出　　处：《Chinese Herbal Medicines》2014年第4期319-323,共5页中草药（英文版）

基　　金：National Natural Science Foundation of China (30572322);Natural Science Foundation of Yunnan Province (2005C0036Q)

摘　　要：Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-（1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside（1）, deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-（1→4）-β-D-thevetopyranosyl-（1→4）-α-D-oleandropyranoside（2）, and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-（1→4）-α-D-oleandropyranoside（3）, respectively. Conclusion Compounds 1-3 are new compounds.Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-（1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside（1）, deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-（1→4）-β-D-thevetopyranosyl-（1→4）-α-D-oleandropyranoside（2）, and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-（1→4）-α-D-oleandropyranoside（3）, respectively. Conclusion Compounds 1-3 are new compounds.

关 键 词：Asclepiadaceae Cynanchum otophyllum C21 steroidal glycoside 

分 类 号：R284[医药卫生—中药学] O657.7[医药卫生—中医学]