Chemical Constituents with Antihyperlipidemic Activities from Desmodium triquetrum  

作　　者：Jia-ni Wu Guo-xu Ma Hai-long Li Chong-ming Wu Yin-feng Tan Ting-ting Zhang Feng Chen Peng Guo Xiao-po Zhang 

机构地区：[1]Research Center on Life Sciences and Environmental Sciences,Harbin University of Commerce [2]School of Pharmaceutical Science,Hainan Medicinal University [3]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College

出　　处：《Chinese Herbal Medicines》2014年第4期324-327,共4页中草药（英文版）

基　　金：National Natural Science Foundation of China (81202994,81001437);China Postdoctoral Science Foundation (2012M510361);Technological Large Platform for Comprehensive Research and Development of New Drugs in the Twelfth Five-Year Significant New Drugs Created Science and Technology Major Projects (2012ZX09301-002-001-026)

摘　　要：Objective To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities. Methods The constituents of D. triquetrumwere isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells. Results Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6＇-O-cis-p-coumaroyl- 3,5-dihydroxyphenyl-β-D-glucopyranoside （1）, tadehaginoside （2）, rutin （3）, quercetin-3-O-β-D-glucopyranoside （4）, quercetin-3-O-β-D-galactopyranoside （5）, 6-O-（E）-p-hydroxy-cinnamoyl-β-glucose （6）, 6-O-（E）-p-hydroxy-cinnamoyl-α-glucose （7）, kaempferol-3-O-β-D-rutinoside （8）, and 3-O-β-D-galacopyranosyl （6-1）-α-L- rhamnosyl quercetin （9）. Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides. Conclusion Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.Objective To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities. Methods The constituents of D. triquetrumwere isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells. Results Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6＇-O-cis-p-coumaroyl- 3,5-dihydroxyphenyl-β-D-glucopyranoside （1）, tadehaginoside （2）, rutin （3）, quercetin-3-O-β-D-glucopyranoside （4）, quercetin-3-O-β-D-galactopyranoside （5）, 6-O-（E）-p-hydroxy-cinnamoyl-β-glucose （6）, 6-O-（E）-p-hydroxy-cinnamoyl-α-glucose （7）, kaempferol-3-O-β-D-rutinoside （8）, and 3-O-β-D-galacopyranosyl （6-1）-α-L- rhamnosyl quercetin （9）. Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides. Conclusion Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.

关 键 词：antihyperlipidemic activities 6＇-O-cis-p-coumaroyl-3 5-dihydroxyphenyl-β-D-gluco-pyranoside Desmodium triquetrum 6-O-（E）-p-hydroxy-cinnamoyl-β-glucose 6-O-（E）-p-hyd roxy-cin namoyl-α-glucose 

分 类 号：R284[医药卫生—中药学]