小儿病毒性脑炎患者脑脊液中S-100B蛋白和MMP-9检测的临床意义  

Significances of qualitative determination of S-100B protein and MMP-9 in cerebrospinal fluid of children with viral encephalitis

作　　者：王雷生[1] 高欣义[1] 刘娟[1] 杨昭华[1] 丁红芳[1] 

机构地区：[1]东营市胜利油田中心医院儿科,山东东营257034

出　　处：《海南医学》2014年第21期3183-3185,共3页Hainan Medical Journal

摘　　要：目的探讨脑脊液中S-100B蛋白、基质金属蛋白酶-9(MMP-9)检测在小儿病毒性脑炎诊断中的临床价值。方法选取病毒性脑炎患儿34例,分为重症组11例和轻症组23例,选取排除颅内感染患儿19例为对照组,采用酶联免疫吸附法检测脑脊液中S-100B蛋白和MMP-9含量。结果病毒性脑炎组患儿脑脊液S-100B蛋白、MMP-9的水平均显著高于对照组(P<0.01);病毒性脑炎重症组脑脊液S-100B蛋白、MMP-9的水平均显著高于轻症组(P<0.01)。结论 S-100B蛋白、MMP-9参与病毒性脑炎的发病过程,联合检测对小儿病毒性脑炎的病情严重程度判断及预后评估具有重要参考价值。Objective To study the clinical significance of the qualitative determination of S-100B protein and MMP-9 in cerebrospinal fluid （CSF） of children with viral encephalitis （V＇E）. Methods Thirty-four children with viral encephalitis were selected, which were divided into severe group （11 cases） and mild group （23 cases）. Another 19 children without VE were selected as the control group. The level of S-100B protein and MMP-9 in cerebrospinal fluid were determined under the enzyme-linked immunosorbent assay. Results CSF S-100B protein, MMP-9 levels were significantly higher in the two groups of children with viral encephalitis than the control group （P〈0.01）, which were also significantly higher in severe group than mild group （P〈0.01）. Conclusion S-100B protein, MMP-9 are involved in the pathogenesis of viral encephalitis, the joint detection of which provides significant refer- rence for evaluating the disease severity and prognosis.

关 键 词：儿童 病毒性脑炎 脑脊液 S-100B蛋白 基质金属蛋白酶-9 

分 类 号：R726.1[医药卫生—儿科]